Abstract 19449: Real World Blood Pressure Variability in Over 56,000 Individuals With Nearly 17 Million Measurements
Introduction: Visit-to-visit and day-to day blood pressure variability (BPV) are known to be associated with an increased risk of stroke, coronary events, and mortality independent of the mean blood pressure (BP). However, current data were acquired in the setting of clinical trials or registry.
Hypothesis: Our goal was to investigate the real world characteristics of BPV.
Methods: We included 56,365 users of Withings’ Wireless Blood Pressure Monitors from US, France, Germany, UK, and 181 other countries who have at least 20 BP measurements separated in time by at least 1 month. We computed standard deviation (SD), coefficient of variation (CV), maximum BP, and maximum minus minimum BP difference (MMD) as an intra-individual BPV index.
Results: We analyzed 16,904,844 BP measurements data (median number of BP measurements per person: 146, IQR 73-321). BPV index were higher in female compared with male (p<0.001) and increased with age (p<0.001). In addition, there was significant difference according to geographic location (p<0.001). Compared to weekend, weekday BPV index were higher, and this finding was more prominent in female participants (p=0.001). In multivariate analysis, BPV index were significantly associated with age, gender, geographic location, and mean BP values. The distribution of BPV index according to age and systolic BP as described by CV and MMD are shown (Figure).
Conclusions: We characterized BPV using the largest ever-reported data set of patient collected, real world BP data that will help establish reference values for BPV index and variables that influence it.
Author Disclosures: K. Kim: None. N. Nikzad: None. N. Wineinger: None. B. Brouard: Employment; Significant; Withings. M. Vegreville: Employment; Significant; Withings. A. Chieh: Employment; Significant; Withings. A. Normand: Employment; Significant; Withings. N. Schmidt: Employment; Significant; Withings. E.J. Topol: None. S. Steinhubl: None.
- © 2016 by American Heart Association, Inc.