Abstract 19178: Temporal Trends in Age at First-Ever Ischemic Stroke
Introduction: While stroke incidence has declined overall, increases in incidence in those <55 years have been observed. This trend may translate into a lower average age at stroke onset and more years of stroke-related disability. Limited data exist on contemporary US trends in age at stroke onset. We explored trends in age at first-ever ischemic stroke using 13 years of data from a bi-ethnic population-based stroke study.
Methods: Cases of first-ever ischemic stroke (n=3,496) were identified from 7 hospitals in the BASIC Project (January 1, 2000-June 30, 2012). Mean difference in prevalence of risk factors between 2000 and 2012 year was evaluated using linear models with robust standard errors. Trends in age at stroke were modeled non-parametrically in generalized additive models (GAMs) overall and by ethnicity (Mexican American (MA) and non-Hispanic white (NHW)). Effect modification by ethnicity was tested in GAMs.
Results: From 2000-2004, mean age at stroke decreased and then stayed virtually unchanged from 2005-2009. Since 2009, mean age at stroke declined slightly. Over the 13 years, mean age at stroke significantly decreased from an average of 71.7 years in 2000 to an average of 69.3 years in 2012. Ethnicity modified the trends (p<0.001), with NHWs experiencing greater declines (Figure 1). The prevalence of uninsured, atrial fibrillation, diabetes, high cholesterol, hypertension, and smoking increased significantly from 2000 to 2012.
Conclusions: The observed declines in age at stroke suggest that lifetime stroke burden is increasing. Reasons for this trend should be explored, and efforts should be made to prevent and control risk factors in the midlife.
Author Disclosures: C. Li: None. J. Baek: None. L. Morgenstern: None. L. Lisabeth: None.
- © 2016 by American Heart Association, Inc.