Abstract 18961: Racial Differences in Plasma Ntprobnp Levels: The Regards Study
Background: Natriuretic Peptides (NPs) are natriuretic and vasodilatory hormones synthesized from the heart. Whether NP system is endogenously suppressed in blacks free of prevalent cardiovascular disease (CVD) is not well established. We hypothesized that plasma N-terminal-pro B type NP (NTproBNP) levels are lower in black compared to white participants of the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study.
Methods: NTproBNP levels were measured at baseline in 4,415 REGARDS random cohort participants. Subjects with prevalent CVD (including heart failure, coronary artery disease, stroke, transient ischemic attack, atrial fibrillation, peripheral vascular disease and aortic aneurysm), cancer, and renal dysfunction were excluded from this analysis. Among the remaining 2,188 individuals, we estimated racial differences using natural log transformed NTproBNP levels as the dependent variable in linear regression models. White race was chosen as reference and percentage difference (with 95% confidence interval) was calculated.
Results: Baseline characteristics of the population studied by race are shown in the Table. The median NTproBNP levels in blacks were significantly lower than whites; 55 pg/ml (26-121) vs.70 pg/ml (37-138), p<0.001. Natural log NTproBNP levels were up to 26% lower in blacks as compared to whites in multivariable models (Figure, p<0.001).
Conclusion: Plasma NTproBNP levels are significantly lower in blacks as compared to whites. The contribution of endogenous suppression of NP system on CVD in blacks remains to be established.
Author Disclosures: N.S. Bajaj: None. S.E. Judd: None. G. Arora: None. A. Bennett: None. O.M. Gutiérrez: None. S.D. Prabhu: None. G. Howard: None. V.J. Howard: None. M. Cushman: None. P. Arora: None.
- © 2016 by American Heart Association, Inc.