Abstract 18924: Porcine Model of Aortic Coarctation: Treatment With Novel Biodegradable Stent Up to 12mm Diameter
Introduction: A novel double opposing helical (DH) biodegradable stent (BDS) made of poly-l-lactic-acid can be fabricated to larger diameters needed for use in congenital heart disease. Study aims were: 1. Create a model of coarctation of aorta (CoA) in minipigs. 2. Evaluate feasibility of stent implantation (DH BDS and metal) and assess mid-term results and inflammatory profile.
Hypothesis: DH BDS will maintain structural integrity to treat porcine CoA.
Methods: Via left lateral thoracotomy, CoA was created in 7 Yucatan minipigs (7-9 kg) by resecting a portion of the aortic wall. Stents were implanted 6-8 weeks later. Assessment included: angiography, intravascular ultrasound and histopathology.
Results: All 7 animals survived the CoA creation surgery and underwent successful stent implantation (4 DH BDS and 3 metal) via carotid (5) and femoral (2) access. 1 planned non-survival animal underwent a 10-mm metal stent implantation that successfully relieved the CoA. The remaining 6 minipigs underwent successful DH BDS (4) or metal stent (2) implantations with CoA relief. 2/6 died within 24 hours due to anesthesia and vascular access complications. The 4 survivors recovered well. At 6 months follow up, 1 animal post 12 mm DH BDS implantation, showed good apposition with vessel luminal patency and mild-moderate inflammatory response. The other 3 survivors with 10mm diameter stents (2 DH BDS and 1 metal) are well with planned evaluation at 12 months.
Conclusion: A resection CoA model was successfully performed. Feasibility to treat the CoA with a DH BDS at diameters 10-12mm is established. Long term follow-up and miniaturization to decrease the DH BDS crossing profile is needed.
Author Disclosures: S.R. Veeram Reddy: Research Grant; Significant; AHA SouthWest Affiliate - Beginning Grant-In-Aid Award. T.R. Welch: Other; Significant; Patent holder for the novel stent design. J. Wang: None. M. Riegel: None. J. Richardson: None. J.M. Forbess: None. A.W. Nugent: None.
- © 2016 by American Heart Association, Inc.