Abstract 18878: Statin Use and the Risk of Cataracts: A Systematic Review and Meta-Analysis of Cohort and Case-Control Studies
Objective: To determine whether statin use is correlated with the increased risk of cataracts.
Methods: A systematic search of the electronic databases PubMed, EMBASE, and the Cochrane Library through January, 2016. Methodological quality was assessed by the Newcastle-Ottawa Scale(NOS). Weighted averages were reported as relative risk (RR) with 95% confidence intervals (CIs). Statistical heterogeneity scores were assessed with the standard Cochran’s Q test and the I2 statistic. Publication bias was evaluated by the Egger’s test. Subgroup analysis was performed based on study design, type of statin, the methodological quality of the study, study location, gender, outcome and outcome assessment method.
Results: A total of 12 studies involving 3,525,000 patients were included in this meta-analysis. The pooled estimates of the included studies indicated that the use of statins might increase the risk of cataracts (RR, 1.15, 95% CI, 1.08-1.23). The sensitivity analysis confirmed the stability of the results. Heterogeneity was found among the studies without evidence of publication bias presented (P>0.05). Most of subgroup analysis results were consistent with the overall results. Subgroup analyzing results indicated that heterogeneity might be partially attributed to the type of statin and the methods for outcome assessment.
Conclusions: The results in this analysis suggests statin use is associated with a 15% increase in the risk of cataracts. However, the RR is low and cataract surgery is effective and well-tolerated, this association should be disclosed but not be considered as a deterrent for the use of statins for cardiovascular risk reduction when warranted.
Author Disclosures: S. Yu: None. Y. Chu: None. G. Li: None. L. Ren: None. Q. Zhang: None. L. Wu: None.
- © 2016 by American Heart Association, Inc.