Abstract 18837: Effect of Life-Course Interactions Between Sex, Age, and Lipoprotein Profiles on Mid-Life Physical Performance
Introduction: The life-course effects of serum cholesterol and lipoprotein levels on physical performance during adulthood have not been well-documented in bi-racial populations. In this study, we had the unique opportunity within the Bogalusa Heart Study (BHS) to analyze five decades of follow-up from childhood that included repeated lipid measurements utilizing enzymatic methods.
Methods: The objective of this analysis was to present the association of lipoprotein profiles, as characterized by their intersections with race, sex, and age, with mid-life physical performance, measured using the short physical performance battery (SPPB) - a composite score combining adult balance testing, walking speed, and chair stands. Using generalized estimating equation models across multiple life-course measurements from 1973-2015, these associations and interactions with lipoproteins on adult physical performance were tested.
Results: At mid-life follow-up in n=876 BHS participants, mean (SD) total serum cholesterol, LDL-C, and HDL-C were 192(40) mg/dL, 114(35) mg/dL, and 52(17) mg/dL. In models across repeated life-course measurements (mean = 8.3 repeated measurements/ participant), HDL-C was significantly lower in participants who later exhibited poor physical performance as middle-aged adults (p<.001). More importantly, this relationship was significantly modified (p<.001) by both age and sex, but not race (p=.09). Men under 30 years of age showed decreasing physical performance with increasing HDL-C, while men over 30 showed the opposite relationship. Conversely, women of all ages trended towards better physical performance with increasing HDL-C.
Conclusions: This characterization enforces that lipoproteins are crucial life-long components of health that are modified by age, and there are likely important differences between males and females in the manner in which HDL-C in young adulthood affects mid-adult physical performance.
Author Disclosures: B.D. Pollock: None. P. Stuchlik: None. C. Fernandez Alonso: None. R. Barshop: None. A. Hussain: None. T. Shu: None. J. Guralnik: None. J. Gustat: None. L.S. Webber: None. W. Chen: None. E.W. Harville: None. L.A. Bazzano: None.
- © 2016 by American Heart Association, Inc.