Abstract 18805: Prognostic Value of Persistent Hyponatremia in Patients With Chronic Heart Failure: A Prospective Comparative Study With Platelet To Lymphocyte Ratio
Backgrounds: Hyponatremia is associated with mortality in chronic heart failure (CHF) pts, but the prognostic significance of persistent hyponatremia (per-hypoNa) remains to be unclear. Platelet-to-lymphocyte ratio (PLR) is a systemic inflammatory marker, which has recently been investigated as new predictor for poor cardiovascular outcomes. However, there is no information available on the prognostic significance of combining per-hypoNa and PLR in CHF pts.
Methods: We studied 132 CHF outpatients with LVEF <40% in our prospective cohort study. PLR was measured at entry. We also measured serum sodium concentration at entry and every 6month for the initial 3 years. Per-hypoNa was defined that hyponatremia (≤135mEq/L) was observed for more than 6 months.
Results: During a follow up period of 8.2±4.1 years, 39 patients had cardiac death. At multivariate Cox analysis, per-hypoNa (p=0.02) and PLR (p=0.007) were significantly independently associated with cardiac death. Pts with both high PLR(>143.4 determined by ROC analysis: AUC 0.63[0.56-0.72]) and per-hypoNa had a significantly greater risk of cardiac death than those with either of these variables (100% vs 45% p=0.02, adjusted HR 4.4 [1.1-16.5]). Furthermore, pts with either of these variables also had a significantly greater risk of the mortality than those with none of them (45% vs 22% p=0.003, adjusted HR 2.6 [1.3-5.1]).
Conclusion: The combination of persistent hyponatremia and PLR could provide the improved prediction of cardiac death in CHF pts.
Author Disclosures: M. Seo: None. T. Yamada: None. T. Morita: None. Y. Furukawa: None. S. Tamaki: None. Y. Iwasaki: None. M. Kawasaki: None. A. Kikuchi: None. T. Kondo: None. Y. Sato: None. T. Ozaki: None. E. Fukuhara: None. I. Ikeda: None. M. Fukunami: None.
- © 2016 by American Heart Association, Inc.