Abstract 18730: Vitamin D and Cardiovascular Mortality: An Individual Participant Data Meta-Analysis With Standardized 25-Hydroxyvitamin D
Background: Vitamin-D deficiency (25(OH)D) is associated with an increased risk for cardiovascular (CV)-mortality. Nevertheless cut-off values remain debated and interventional studies reported largely negative results. We therefore performed an individual-participant meta-analysis investigating the association between standardized 25(OH)D and CV-mortality.
Methods: In a European consortium of eight prospective studies, including seven general population and one hospital based cohort, we used vitamin-D standardization program protocols to standardize 25(OH)D measurements. Meta-analyses using individual participant data (IPD) were performed to study the associations of 25(OH)D with CV-mortality implementing parametric (Weibull) survival model and restricted cubic splines
Results: We analysed 26916 study participants (median age: 61.6years, 58%females, median 25(OH)D: 53.8nmol/L). During a median follow-up of 10.5years, 1810 fatal CV event occured. Excessively increased CV-risk was seen in patients with 25(OH)D levels below 30nmol/L (HR=2.21 95%CI 1·50-3·26), representing 11.0% of the population studied.
Conclusions: In the IPD meta-analysis using standardized measurement of 25(OH)D we observed an association between 25(OH)D ≤30nmol/L and increased risk of CV-mortality. Treating individuals with 25(OH)D levels ≥50nmol/L, which are not associated with a substantially increased CV-risk, is unlikely to result in a clinically meaningful benefit.
Registered at ClinicalTrials.gov number NCT02438488.
Funding source: The European Commission under its Seventh Framework Programme (ODIN; Grant Agreement No. 613977).
Author Disclosures: M.R. Grubler: None. M. Gaksch: None. R. Jorde: None. W. März: None. V. Gudnason: None. J. Dekker: None. L. Rejnmark: None. M. Thamm: None. M. Kiely: None. K. Cashman: None. S. Pilz: None.
- © 2016 by American Heart Association, Inc.