Abstract 18716: Cardiovascular Benefits of Total and Domain Specific Physical Activity in Resource Poor Settings: Findings From a 7-Year Prospective Study of 0.5 Million Chinese Adults
Introduction: Previous studies of physical activities (PA) were mainly focused on recreational exercise and limited to high-income countries. In developing countries such as China recreational PA accounts for a much smaller proportion of total energy expenditure than work-, commuting- or household-related PA.
Hypothesis: Different domains of physical activity are associated with reduced CVD mortality risk in Chinese adults.
Methods: The prospective China Kadoorie Biobank Study recruited >0.5 million adults aged 30-79 years from 10 (5 urban, 5 rural) diverse areas in China, tracking cardiovascular disease (CVD) mortality for 7 years. Cox regression analyses were used to produce adjusted hazard ratios (HRs) for the association of CVD mortality (n = 7543) with levels of total and domain-specific PA among 489,762 participants without prior CVD at baseline.
Results: Overall, the mean total PA was 21.7 MET-hr/day, with work-, commuting-, household- and recreational-related physical activities accounting for 14.0, 1.6, 5.3 and 0.8 of total PA, respectively. Total PA showed an approximately log-linear inverse relation with CVD mortality, with each 10 higher MET-hr/day associated with 17% (95% CI 14-19) lower risk. The effects appeared to be similar across different domains of PA, with adjusted HRs for top versus bottom tertiles of domain-specific PA being 0.63 (0.59-0.67), 0.78 (0.74-0.82), 0.77 (0.73-0.81) respectively for work-, commuting-, and household PA. For recreational-related PA the HR was 0.87 (0.81-0.93) for those that did some activity compared to those that did none. After correcting for regression dilution bias, each standard deviation higher MET-hr/day increase in usual work-, commuting- and household-related PA was associated with 28%, 11%, and 19% lower CVD mortality respectively. The results differed little by area and gender, and persisted after excluding individuals with other prior chronic disease or the first two years of follow-up.
Conclusions: In Chinese adults, higher physical activity of any type was associated with a lower CVD mortality. These findings suggest that in resource-poor settings targeted strategies to increase levels of any physical activity including household and commuting could have a major health benefit.
Author Disclosures: D. Bennett: None. L. Li: None. H. Du: None. Y. Gou: None. Z. Bian: None. J. Chen: None. Z. Chen: None.
- © 2016 by American Heart Association, Inc.