Abstract 18555: Sleep Duration and Risk of Coronary Heart Disease, Sudden Cardiac Death and All-Cause Mortality
Introduction: Sleep duration has been shown to be associated with mortality, however do similar observations extend to cause specific events including coronary heart disease (CHD) or sudden cardiac death (SCD) and whether they remain independent of traditional cardiovascular risk factors is unclear.
Hypothesis: To examine the relationship between sleep duration and risk of CHD, sudden cardiac death and all-cause mortality.
Methods: Sleep duration was reported at baseline in 2,354 men aged 42-61 years from the Kuopio Ischemic Heart Disease study. Clinical characteristics and follow up data were collected and multivariate Cox proportional hazards modelling was used to test associations.
Results: A total of 314 fatal CHD events, 201 sudden cardiac events and 997 all-cause mortality events were reported during a median follow-up of 23.2 years. Age-adjusted hazard ratio (HR) comparing the top quartile (> 10 hours) of sleep duration versus the bottom quartile (<8 hours) was 1.58(95% CI:1.01-1.95) for CHD, 1.43(95% CI:1.0-2.04) for SCD and 1.42(95% CI:1.21-1.68) for all-cause mortality. Further adjustment for cardiovascular risk factors including systolic blood pressure, history of cardiovascular disease, diabetes, smoking, alcohol use, renal function and serum LDL cholesterol attenuated these associations further to 1.24(95% CI:0.91-1.68) for CHD 1.08(95% CI:0.75-1.56) for SCD and 1.26(95% CI: 1.07-1.49) for all-cause mortality. These findings were comparable across age, body mass index, smoking, diabetes, cardiovascular disease and other clinical risk factors at baseline.
Conclusions: Longer duration of sleep was associated with significant all-cause mortality independent of cardiovascular risk factors. However mechanistic links between these findings remains to be explored further.
Author Disclosures: H. Khan: None. S. Kunutsor: None. K. Savonen: None. J.A. Laukkanen: None.
- © 2016 by American Heart Association, Inc.