Abstract 18461: Seasonal Variation of Pulmonary Hypertension Hospitalizations
Background: Hospitalizations for pulmonary hypertension (PH) have been steadily rising over the past decade. Though previous studies have described seasonal variations for several cardiovascular diseases, but there is no data showing similar trends in patients with PH. We reviewed a large national hospitalization database to determine whether rates of PH have varied by season over the past decade.
Methods: The nationwide Inpatient Sample (NIS) database was used to estimate annual number of hospitalizations from 2000 - 2012. PH-related hospitalizations were identified based on principal diagnosis of ICD-9 codes 416, 416.8, or 416.9. Further we sub-divided the number of hospitalizations into idiopathic pulmonary hypertension (IPAH) defined by ICD -9 code 416.0 and using both codes 416.8 and 416.9 for secondary pulmonary hypertension (SPH). The frequency of hospitalization per month cumulative over 12 years was calculated and divided by number of days in that month to determine the mean hospitalizations per day for each month. All calculations were carried out using the weighted estimates approximating nationwide population estimates.
Results: An estimated 156, 948 hospitalizations with primary diagnosis of PH occurred in the US from 2000 to 2010. Figure 1 shows the number of hospitalizations per day stratified by season for IPAH, SPH, and PH. The number of hospitalization was highest in winter and lowest in autumn. The mean number of hospitalizations in each day was highest in April (IPAH - 96 per day, SPH - 454 per day and PH - 549 per day) and thereafter the hospitalizations rate dropped to nadir in December (IPAH - 71 per day, SPH - 401 per day and PH - 473 per day).
Conclusion: We identified for the first time in US an impressive pattern of seasonal variation in hospitalizations for PH with a notable increase in winter. Further efforts needs to be done to identify triggers and methods to determine the relationship of these variations and reduce its burden on health care system.
Author Disclosures: M. Pahuja: None. R.G. Soni: None. A. Handa: None. N. Bhatia: None. S. Agrawal: None. N. Hussain: None. D. Patel: None. S. Kamdar: None. A. Kalya: None.
- © 2016 by American Heart Association, Inc.