Abstract 18438: Hypercoagulability in Anticoagulation-Naive Young Paroxysmal Atrial Fibrillation Patients
Background: Atrial fibrillation (AF) is associated with thromboembolic complications. Whether the prothrombotic state is due to AF itself or is caused by coexistent cardiovascular diseases remains unclear. Our aim was to assess the difference in coagulation activity between low risk AF patients (onset AF < 60 years, CHA2DS2-VASc score of 0) and healthy controls.
Methods: A total of 44 patients with paroxysmal AF and a CHA2DS2-VASc score of 0 were 1:1 matched with healthy controls without AF based on age and gender. All patients were in sinus rhythm at the time of bloodsampling. None of the AF and control patients received oral anticoagulation therapy. Analyzed coagulation markers, selected for detecting upstream signals of hypercoagulability, were factor IXa-antithrombin complexes (Factor IXa:AT) and factor Xa-antithrombin complexes (Factor Xa:AT).
Results: Mean age was 44±12 years and 42 (47.7%) were men. AF patients had significant higher levels of Factor IXa:AT than healthy controls (209.0 [IQR 174.4-287.3] pM vs. 136.3 [IQR 109.6-157.3] pM, p<0.001). No significant differences were found in Factor Xa:AT levels between AF patients and healthy controls (536.5 [IQR 483.8-684.3] pM vs. 549.3 [IQR 470.1-605.1] pM, p=0.29).
Conclusion: These data suggests that in young patients with paroxysmal AF and a low risk for stroke hemostatic changes, indicated by increased factor IX activation, occur. These changes are even present when they are in sinus rhythm, reflecting a prethrombotic state.
Author Disclosures: A.H. Hobbelt: None. M. Rienstra: None. H.J. Crijns: None. R.R. De With: None. E.A. Dudink: None. H. Ten Cate: None. R. Van Oerle: None. H.M. Spronk: None. I.C. Van Gelder: None.
- © 2016 by American Heart Association, Inc.