Abstract 18426: Improved Aerobic Capacity up to a Year Following an Exercise Intervention in Patients Undergoing Aortic Valve Replacement for Aortic Stenosis
Introduction: In the RASP (Rehabilitation in Aortic Stenosis Patients) study, we investigate effects of supervised exercise compared to physical activity recommendations on aerobic capacity (peakVO2) and physical activity level (PAL) in patients following open heart surgery for aortic stenosis. We hereby present preliminary results from a first interim analysis.
Methods: So far, 12 patients (median age 63 years, 9 males) have been randomized equally to either 12 weeks of exercise on a bicycle ergometer 45 minutes 3 times/week (SupEX) or to receive recommendations regarding physical activity following cardiac surgery (HomeEX). Patients performed a maximal cardiopulmonary exercise test (CPET) PRE, POST and 1-YEAR after the intervention which started 6 weeks after the surgery. Physical activity level (PAL) was inquired at the same occasions with the IPAQ questionnaire.
Results: Data from CPETs are presented in figure 1 (table). At 1-YEAR, median (range) improvement from PRE in peakVO2 (mL/kg/min) was 17% (15-20%, p=0.043) in SupEX and 11% (0-33%, p=0.116) in HomeEX. A trend toward increased PAL in both groups at POST and 1-YEAR was seen, together with a trend toward higher total PAL in the SupEX than in the HomeEX group following intervention, although not statistically significant (figure 2).
Conclusions: This interim analysis in the RASP study shows that both patients performing supervised exercise training and patients receiving physical activity recommendations improve in peakVO2. Non-statistically significant trends toward larger improvement in peakVO2 and PAL at 1 year after supervised exercise training than after physical activity recommendations were seen.
- Aortic valve stenosis
- Surgical treatment
- Cardiopulmonary exercise testing
- Exercise tests and training
Author Disclosures: K. Hedman: None. S. Borg: None. E. Nylander: None. É. Tamás: None.
- © 2016 by American Heart Association, Inc.