Abstract 18424: Ventricular Shape Correlates to Arrhythmic Events in ARVC Patients
Introduction: Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) patients undergo ventricular shape remodeling as the disease progresses. Since this remodeling may be indicative of arrhythmic risk, we investigated the relationship between computationally calculated shape features in ARVC patients and history of arrhythmias.
Methods: A population of 27 ARVC patients was studied (13 male, age 38 ± 14 years, 12 with a history of VT or VF). Three-dimensional (3D) models of the LV endocardium and epicardium, as well as the RV endocardium, were created at ES and ED from CMR recordings (Figure a). Partial least squares analysis was applied to the 3D ES geometry together with measures of RVEDV, RVESV, RVEF, LVEDV, or LVEF, to compute common shapes features in the population. For visualization purposes, each shape feature was plotted in 3D from low to high values of the feature. Correlations for volume/EF measures alone and these measures supplemented with the computed common shape features were calculated against history of arrhythmias.
Results: A strong correlation was found between VT/VF and the combination of LVEDV with shape, while volumes alone did not correlate with VT/VF (Figure b). Similarly, moderate correlation was found when RVEF was combined with shape, while not for RVEF alone. Shape also improved the correlation with VT/VF for RVEDV and RVESV. Visualization of the RVEDV shape feature showed RV inlet and RV outlet dilation, and RV freewall bulging (Figure c).
Conclusions: Supplementing traditional measures of structural remodeling with advanced shape analysis provides better clinical correlation to VT/VF than traditional measures alone. Shape analysis methods could be important tools to better predict arrhythmias in patients and provide visualization of ARVC ventricular remodelling.
Author Disclosures: K. McLeod: None. S. Wall: None. I.S. Leren: None. J. Saberniak: None. K.H. Haugaa: None.
- © 2016 by American Heart Association, Inc.