Abstract 18416: Serum Adropin Level is a Predictor of Exercise Training-Induced Improvement of Arterial Stiffness in the Middle and Older Adults
Introduction: In our recent study, aging-induced arterial stiffening was gradually decreased by aerobic exercise. Furthermore, circulating level of adropin, a regulator of endothelial nitric oxide, was elevated by regular aerobic exercise and this increase in adropin was associated with the effect of exercise training on arterial stiffness and nitric oxide (NO) production in elderly adults. However, the time course of elevation of serum adropin in response to exercise training in middle-aged and older adults remains unclear.
Purpose: This study aimed to determine the time course of changes in serum adropin level related to exercise-training effects of arterial stiffness in healthy middle-aged and older adults.
Methods: Thirty-one Japanese healthy middle-aged and older subjects (67 ± 1 years) were randomly divided into two groups: exercise intervention and sedentary controls. Subjects in the training group completed 8-week of aerobic exercise training (60-70% peak oxygen uptake [VO2peak] for 45 min, 3 days/week). We evaluated plasma nitrite/nitrate (NOx) and serum adropin concentrations and carotid-femoral pulse wave velocity (cfPWV), measured every 2 weeks for 8-week in the training group.
Results: cfPWV was gradually declined from baseline to 8-week and significantly decreased after 6-week intervention (P < 0.05). Plasma NOx level was gradually elevated during exercise intervention and significantly increased from baseline at weeks 6 and 8 (P < 0.05). Interestingly, serum adropin level was significantly increased from after 4-week intervention (P < 0.05). Furthermore, the exercise training-induced reduction in serum adropin level was positively correlated with the change in plasma NOx level after 6-week (r = 0.59, P < 0.05) and 8-week (r = 0.68, P < 0.01). Additionally, there was a positive correlation between the change in serum adropin level and cfPWV after 8-week (r = –0.50, P < 0.05).
Conclusions: These results suggest that the serum adropin level was increased at the early stage of exercise training intervention and was associated with exercise training-induced alteration of arterial stiffness in the middle and older adults. Thus, serum adropin level may be a predict biomarker of exercise training-induced improvement of arterial stiffness.
Author Disclosures: S. Fujie: None. N. Hasegawa: None. K. Sanada: None. T. Hamaoka: None. M. Iemitsu: None.
- © 2016 by American Heart Association, Inc.