Abstract 18390: Changes in Leisure-Time Physical Activity Are Associated With Risk of Incident Atrial Fibrillation - The Atherosclerosis Risk in Communities Study
Introduction: Greater leisure-time physical activity (LTPA) is associated with lower risk of cardiovascular disease. However, the association of LTPA, and changes in LTPA over time, with incident atrial fibrillation (AF) in a community-based, non-athletic population is unclear.
Hypothesis: Persons with persistently poor activity in adult life have higher incident AF relative to those with persistently ideal activity.
Methods: Among 12,228 participants in the Atherosclerosis Risk in Communities Study who were free of AF at visit 3, self-reported LTPA assessed at visits 1 and 3 were categorized as poor, intermediate, or ideal LTPA using American Heart Association (AHA) criteria. Change in LTPA categories and average LTPA over the 6 year period were related to incident AF with multivariable Cox models.
Results: The mean age was 60.4 ± 5.7 years. Over a median follow up of 16.7 years, incident AF occurred in 1518 participants. Compared to those with persistently ideal activity over 6 years, participants with persistently poor activity (HR 1.26; CI 1.07, 1.47) and who decreased activity from ideal to poor (HR 1.32; CI 1.07, 1.62) had a higher risk of incident AF after adjusting for age, sex, race, prior coronary disease, prior heart failure, diabetes, systolic blood pressure, and anti-hypertensive medication use. Those who increased activity from poor to ideal (HR 1.12; CI 0.91, 1.37) did not have a significantly different risk of AF compared to those with persistently ideal activity. Age modified the association of LTPA with incident AF such that higher average activity (MET-min/week) was associated with a lower risk of incident AF in younger participants, but this association weakened in older individuals (p interaction for age = 0.007, Figure).
Conclusions: In younger, middle-aged individuals, maintaining average activity levels over 500 MET-min/week, as recommended by the AHA, is associated with a lower risk of incident AF. This relationship weakens with increasing age.
Author Disclosures: S. Hegde: None. B. Claggett: None. T. Biering-Sørenson: None. S. Cheng: None. A.M. Shah: None. L.Y. Chen: None. E.Z. Soliman: None. A. Alonso: Research Grant; Significant; American Heart Association. S.D. Solomon: Consultant/Advisory Board; Significant; Novartis.
- © 2016 by American Heart Association, Inc.