Abstract 18267: Does High Triglycerides/High-Density Lipoprotein Cholesterol Ratio Predict Outcomes in an Australian Population of Patients After Coronary Angiography?
Aims: High Triglycerides (TG) and low high-density lipoprotein cholesterol (HDL-C) are major cardiovascular risk factors. A positive association between elevated TG/HDL-C ratio and all-cause mortality and major adverse cardiovascular events (MACEs) have been reported. However, if high TG/HDL-C ratio can predict outcomes in an Australian population of patients after coronary angiography, has not been reported.
Methods: Baseline biochemistry, detailed demographic and clinical data had been obtained from 850 patients at the time of enrolment into the study. Follow-up information was collected using a questionnaire by contacting patients. Subjects were stratified into two groups of TG/HDL-C ratio by dividing the baseline TG/HDL-C ratio at 2.5. Multivariate cox-proportional hazard models were constructed for all-cause mortality over a median follow-up period of 5.5 years, using TG/HDL-C ratio as a predictor variable and analysing for cardiovascular risk factors. A multivariate logistic regression model for MACEs was constructed to analyse if TG/HDL-C ratio is a risk factor.
Results: Follow up information was obtained from 522 subjects. 482 subjects had baseline TG/HDL-C ratio and were included in the final data analysis. The subjects mean age was 63.4±11 years, 69% were Males, 74.7% were hypertensive, 80.6% had hypercholesterolemia, 29.6% were diabetic, 70.8% had Coronary Artery Disease (CAD) and 68.7% were either active or previous smokers. Baseline TG/HDL- C ratio ranged from 0.21 to 7.73. During the follow-up period, there were 49 deaths. In a multivariate Cox-proportional hazard model after adjusting for gender, age, smoke and history of diabetes, hypertension and hypercholesterolemia, subjects who had a baseline TG/HDL-C ratio ≥2.5 had a 3-fold increased risk of mortality compared to subjects who had a baseline TG/HDL-C ratio ≤2.5. In a multivariate regression model, after adjusting for conventional cardiovascular risk factors, TG/HDL-C ratio was not significantly associated with MACEs.
Conclusion: TG/HDL-C ratio ≥2.5 is a powerful independent predictor of all-cause mortality in this population of patients after coronary angiography. However, TG/HDL-C ratio is not a powerful independent risk factor for MACEs in this study cohort.
Author Disclosures: R. Sultani: None.
- © 2016 by American Heart Association, Inc.