Abstract 18257: Systolic Blood Pressure as a Novel Determinant of Nocturia in Non-Hispanic Black Men
Introduction: Nocturia (awakening one or more times at night to urinate) has been associated with self-reported hypertension and non-Hispanic black race/ethnicity in a small number of prior studies, none of which measured blood pressure (BP).
Methods: To determine if systolic or diastolic BP, or both, are independent determinants of nocturia, in 2,577 black men 35 to 79 years of age being screened in their barbershops for participation in a NHLBI funded barbershop based hypertension intervention trial in Los Angeles, field interviewers; a) obtained accurate measures of BP with a highly rated oscillometric monitor that took 5 successive readings and averaged the last 3; and b) administered an in-person questionnaire that included structured response items on nocturia and its known determinants.
Results: The men had a mean age of 53 ± 0.2 (SEM) years and 1,288 men (50%) had hypertension; of these, 33% were untreated (with BP medication) and another 28% were treated but uncontrolled (BP≥140/90 mmHg). The overall prevalence of any nocturia was high: 77%, ranging from 68% of normotensive men (n=469, mean BP 112/68 mmHg) to 91% of men with treated but uncontrolled hypertension (n=366, mean BP 151/89 mmHg). In stepwise multivariable logistic regression models that accounted for several factors (age, diabetes, enlarged prostate, treatment with BP medication and sleep apnea), systolic but not diastolic BP was found to be an independent determinant of nocturia: for each 10 mmHg increase in systolic BP, the odds of having any nocturia increased by 13%, adjusted odds ratio (aOR) and 95% confidence interval (CI), 1.13, [1.06-1.21]) and the odds of having severe nocturia (≥3 episodes per night), which was present in 16% of the sample, increased by 23% (aOR [95% CI], 1.23 [1.12-1.34]). The effect associated with each 10 mmHg increase in systolic BP was similar to that with each 10-year increase in age.
Conclusion: This study of a large unselected community-based sample of middle-aged and older non-Hispanic black men provides the first evidence that systolic BP constitutes an independent and rather potent determinant of nocturia. Prospective studies are underway to determine if nocturia—and thus sleep quality, and quality of life—improve with effective hypertension management.
Author Disclosures: O.R. Mason: None. K. Lynch: None. M. Rashid: None. A. Reid: None. R.M. Elashoff: None. R.G. Victor: None.
- © 2016 by American Heart Association, Inc.