Abstract 18237: Relationship of Biomarkers: Clinical Depression or Heart Failure?
Introduction: While brain natriuretic peptide (BNP) is linked with heart failure (HF) diagnosis, its role and that of pro-inflammatory cytokines i.e. tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) in clinical depression among HF patients is unclear.
Objective: To evaluate the relationship of clinical depression with BNP, TNF-α, and IL-6 among HF patients.
Methods: In a cross-sectional study, 89 HF patients (age 68.3 ± 11.3 years, left ventricular ejection fraction [LVEF] 39.9% ± 16%, HF duration 40.1 ± 58 months, and 46 [52%] New York Heart Association III/IV, Charlson Cormorbidity Index [CCI] score: 0= 11.8%, 2-3= 36.8% and ≥4 = 51.6%). Presence of clinical depression was measured by Diagnostic Interview Structured Hamilton (DISH). After controlling for significant clinical variables, multiple regression of clinical depression was performed for each of biomarker (BNP, TNF-α, and IL-6), controlling for age, LVEF, HF duration and NYHA class.
Results: None of the biomarkers were significantly associated with the presence of clinical depression (n= 16 [17%]). Brain natriuretic peptide was associated with LVEF (r = .14, β= -.39, p = <.001); TNF-α was associated with HF duration (r = .06, β= .26, p = .01); and IL-6 was associated with CCI (r = .07, β= .21, p = .04).
Conclusion: For this group of HF patients, clinical indicators of HF progression, but not clinical depression or its symptoms, were related to inflammatory biomarkers. Further study is warranted to examine these complex relationships
Author Disclosures: T. Corvera-Tindel: None. L. Doering: None.
- © 2016 by American Heart Association, Inc.