Abstract 18217: Adult Height, Lifestyle and Healthy Aging
Introduction: Adult height has shown directionally diverse associations with several age-related diseases including cardiovascular disease and cancer, as well as mortality. However, it remains unknown how height is associated with overall health and well-being among populations who have survived to older age, and whether lifestyle modulates such relations.
Methods: The current analysis consisted of 52,134 Nurses’ Health Study (NHS) participants without chronic diseases in 1980 and whose health status was updated until 2012. Current height was inquired at NHS study enrollment in 1976. Healthy aging was defined as being free of 11 major chronic diseases and having no reported impairment of subjective memory, physical impairment, or mental health limitations.
Results: Of all eligible study participants, 6,877 (13.2%) were classified as healthy agers. After adjustment for demographics and lifestyle factors, we observed an 8% (95% confidence interval [CI]: 6% to 11%) decrease in the odds of healthy aging per standard deviation (SD, 2.4 inches) increase in height. Compared with the lowest quintile, the odds ratio (95% CI) of achieving healthy aging in the highest quintile of height was 0.80 (0.73 to 0.87; P-trend < 0.001). In addition, we found a significant interaction of height with prudent dietary pattern in relation to healthy aging (P for interaction = 0.005); and among the individual dietary factors characterizing prudent dietary pattern, fruit and vegetable intake showed the strongest effect modification (P for interaction = 0.01). Our joint analyses (Figure) indicated that benefits of higher levels of prudent dietary pattern rich in vegetable and fruit intake appeared more evident among women with shorter height.
Conclusion: Greater height was associated with a modest decrease in likelihood of healthy aging; a prudent diet rich in fruits and vegetables might improve healthy aging especially among women with shorter stature.
Author Disclosures: W. Ma: None. K. Hagan: None. Q. Sun: None. E.B. Rimm: None. L. Qi: Research Grant; Modest; the National Heart, Lung, and Blood Institute (HL071981, HL034594, HL126024), the National Institute of Diabetes and Digestive and Kidney Diseases (DK091718, DK100383, DK078616), the Boston Obesity Nutrition Research Center (DK46200), United States – Israel Binational Science Foundation Grant 2011036, American Heart Association Scientist Development Award (0730094N).
- © 2016 by American Heart Association, Inc.