Abstract 18177: Plasma Levels of Cancer Antigen-125 as a Biomarker of Paroxysmal or Persistent Atrial Fibrillation in Postmenopausal Women
Introduction: Plasma cancer antigen (CA)-125 is a tumor marker that was recently shown to be associated with systolic heart failure and new-onset atrial fibrillation (AF) after myocardial infarction. However, no reports have described the relationship between CA-125 and paroxysmal or persistent AF in healthy postmenopausal women.
Methods: Between 2005 and 2015, 2086 women including 1012 postmenopausal women visited our hospital for annual health check-ups. We excluded patients with systolic dysfunction, chronic inflammatory disease, chronic obstructive pulmonary disease, permanent AF, or other neoplastic diseases. A total of 746 postmenopausal women underwent a thorough physical examination, including biomarkers such as brain natriuretic peptide, high-sensitivity C-reactive protein (hs-CRP), and CA-125
Results: During the 10-year observation period, AF was documented in 31 patients (4.2%). The mean age in patients with AF (75 ± 6 years) was higher than in others (68 ± 8 years). Patients with AF showed significantly higher CA-125 (11.4 ± 6.3 U/ml) and hs-CRP levels (0.10 ± 0.11 mg/dl) compared with patients without AF (7.7 ± 3.2 U/ml, P < 0.01; 0.07 ± 0.08 mg/dl, P < 0.05). Multiple logistic regression analysis revealed aging (odds ratio [OR], 1.12; 95% confidence interval [CI], 1.06-1.20; P < 0.001), plasma CA-125 levels (OR, 1.16; 95% CI, 1.07-1.26; P < 0.001), and hypertension (OR, 2.67; 95% CI, 1.23-5.82; P = 0.01) as independent predictors of AF.
Conclusions: High CA-125 levels might be associated with paroxysmal or persistent AF in healthy postmenopausal women.
Author Disclosures: H. Sekiguchi: None. I. Ishida: None. K. Jujo: None. K. Shimamoto: None. T. Shiga: None. M. Kawana: None. N. Hagiwara: None.
- © 2016 by American Heart Association, Inc.