Abstract 18165: Paroxysmal Atrial Fibrillation Risk Factors and Treatments: What is the Impact on Quality of Life?
Introduction: Paroxysmal Atrial Fibrillation (PAF), compounding cardiac risk factors and their treatments can impact quality of life (QoL). The aim of this study was to assess the impact of PAF treatments (i.e., medications, electrical cardioversions, and ablations) and co-existing risk factors (sleep apnea, diabetes, heart failure, and hypertension) on QoL measures.
Methods: We included 34 adult patients with PAF (76% male, age = 53 ± 10 years) from a larger study examining the use of ECG monitoring for the detection of AF. The SF-36 QoL questionnaire obtained prior to ECG monitoring was used to measure health domain scales and component summary scores. Data were analyzed by t-test and multiple regression.
Results: Overall, QoL domain scores (physical and mental) were close to normal (mean score 50). However, Mental Health (41.4 ± 7.5) and Role Physical (42.7 ± 11.8) were significantly reduced. Patients who had a previous cardioversion scored lower on the bodily pain domain (47.5 ± 10.0 vs. 54.3 ± 7.2, p = 0.03). Physical functioning scores were lower in patients with CHADS2 scores ≥ 2 than in patients with CHADS2 scores of 0 (36.3 ± 7.2 vs. 50.7 ± 9.1, p = 0.0007). Physical functioning scores were also lower in patients taking diuretics (37.0 ± 7.8 vs. 49.9 ± 8.4, p = 0.002) and in patients with sleep apnea (32.8 ± 7.2 vs. 49.6 ± 8.1, p = 0.0004). In the multiple regression analysis, the effects of CHADS2 scores ≥ 2 and sleep apnea remained significant (p = 0.008 and p = 0.0004, respectively). Physical component summary scores were also lower in patients with CHADS2 scores ≥ 2 (40.3 ± 7.4 vs. 51.5 ± 8.3, p = 0.009), those taking diuretics (39.6 ± 6.8 vs. 49.8 ± 9.1, p = 0.01) and in patients with sleep apnea (36.4 ± 7.0 vs. 49.5 ± 8.7, p = 0.007). In the multiple regression analysis only sleep apnea was significant (p = 0.02).
Conclusion: Sleep apnea is a significant factor that lowers QoL physical scores in PAF. Clinicians should aggressively screen and treat sleep apnea in these patients.
Author Disclosures: K.T. Hickey: None. R.R. Sciacca: None. A.B. Biviano: None. W. Whang: None. H. Garan: None. A.P. Frulla: None. N.R. Hauser: None. T.C. Riga: None. P. Gonzalez: None. D.Y. Wang: None.
- © 2016 by American Heart Association, Inc.