Abstract 18156: Normal Heart Dimensions Are Different in African Americans versus Caucasians
Introduction: Normal heart weight (HW) and dimensions are routinely used to determine the presence or absence of cardiac hypertrophy and dilatation during autopsy. However, the definition of “normal” heart has not been determined by race.
Methods: We conducted a retrospective cohort analysis of 6989 cases collected in our registry and evaluated HW, and myocardial dimensions including left ventricular (LV) cavity diameter (CD), ventricular septum (VS) and LV and right ventricular (RV) free wall thickness. We excluded hearts which had evidence of disease such as coronary artery disease, myocardial infarction, post stent implantation, bypass grafts, heart failure, valve disease, myocarditis, cardiomyopathy, and congenital heart disease. Normal heart was defined as an individual dying of unnatural causes and there had to be an absence of heart disease following a complete autopsy. We only included case without histologic presence of myocardium hypertrophy and fibrosis.
Results: Our analysis included 497 African Americans (AA) (60% men [M]) and 613 Caucasians (C) (58% M). Age of AA men (AAM) and C men (CM) was not significantly different (median 40 (IQ 28, 47) vs. 40 (IQ 31, 49) years, p=0.2), while C women (CW) were significantly older than AA women (AAW) (median 43 (IQ 35, 52) years vs. 39 (IQ 31, 48) years, p=0.003), and CM were significantly heavier than AAM (median 85.3 vs. 82.1kg, p=0.05, height similar). There was a good correlation between HW and body weight (BW) (r2=0.25, p<0.0001). Logistic regression analysis showed HW was not significantly different in AA versus C after adjusting for age, body height and BW (HW, median AAW 368 [309, 430] grams, CW 357 [301, 409] grams, AAM 400 [357, 450], CM 430 [383, 465] grams, β -3.1, 95%CI -6.3 to 0.2; p=0.06), however, VS was significantly greater in AA versus C (VS, median AAW 14 mm[13, 15], CW 13 mm [12, 15], p=0.0005, AAM 15 mm [14, 16], CM 15 mm [13, 16], p=0.04) and the differences were more significant in subjects ≤35 years vs.>35 years.
Conclusions: Although heart weight was not different, septal thickness of African Americans was significantly thicker than Caucasians. Our results suggest that the definitions of normal hearts may need to be revised according to race and that further study of differences between AA and C is needed.
Author Disclosures: S. Torii: None. K. Yahagi: None. H. Mori: None. R. Kutys: None. M. Romero: None. F. Kolodgie: None. R. Virmani: None. A. Finn: None.
- © 2016 by American Heart Association, Inc.