Abstract 18151: NIH-Funded Cardiac Arrest Research: A 10-Year Trend Analysis
Background: Cardiac arrest (CA) is a leading cause of death in the U.S., claiming over 500,000 lives annually. Improving survival depends largely on the ability to conduct CA research, and the translation of research findings into practice. Our objective was to provide a descriptive analysis of annual NIH-funding for CA research over the past decade.
Methods: An advanced search within NIH RePORTER for the years 2006-2015 was performed using the following terms: "cardiac arrest" or “cardiopulmonary resuscitation” or “heart arrest” or “circulatory arrest” or “pulseless electrical activity” or “ventricular fibrillation” or “resuscitation". Grants were reviewed and categorized as CA research (yes/no) using predefined criteria. The annual number of CA grants, principal investigators, newly funded grants, trainee grants, non-human subject grants, human-subject grants, and pediatric grants were tabulated. The total NIH investment in CA research was calculated and compared to other leading causes of death within the U.S. The data were analyzed descriptively. Inter-rater reliability between three independent reviewers for funding year 2015 was assessed using Fleiss’s Kappa calculation.
Results: The search yielded 2,693 NIH-funded grants, of which 749 (27.8%) were classified as CA research (Kappa = 0.86). Comparing 2006 to 2015, an increase was seen in the annual number of CA grants (69-81), principal investigators (60-75), individual trainee grants (5-16), and pediatric CA grants (6-16). The total funding for CA research increased from $32.8 M in 2006 to $40.8 M in 2015. This NIH investment in CA research represents approximately 0.13% of the 2015 NIH budget, while stroke and heart disease represent 0.95% and 4.2%, respectively. Per annual death, this investment equates to ~$2,200 for stroke, ~$2,100 for heart disease, and ~$81 for cardiac arrest.
Conclusion: A modest increase in the annual number of NIH-funded CA grants, principal investigators, trainee grants, and pediatric CA grants has occurred over the past decade. Our data suggests that the NIH investment in CA research is substantially less than other leading causes of death in the U.S.
Author Disclosures: R.A. Coute: Other Research Support; Modest; Sarnoff Cardiovascular Research Foundation Fellowship. A.R. Panchal: None. T.J. Mader: Research Grant; Modest; NIH, R21 HL128230. R.W. Neumar: Research Grant; Modest; NIH, R44 HL091606.
- © 2016 by American Heart Association, Inc.