Abstract 18145: The Role Of Exposure To Environmental Pollutants In Racial Disparity In Cardiovascular Risk Factors And Novel Markers
Background: Environmental pollutants are associated with cardiovascular disease (CVD) outcome. However, the mechanisms of these associations, their relationships with CVD risk factors and role in racial disparities are uncertain. We aimed to assess racial CVD disparities in relation to environmental pollutants, CVD risk factors and novel markers.
Methods: Data from the community-based Heart Strategies Concentrating on Risk Evaluation (HeartSCORE) study were used. Exposure to environmental pollutants was determined by measuring accumulation mode particulate matter (PM2.5) and black carbon (BC) in different parts of Pittsburgh and levels were assigned to participants based on their residential locality as determined by their zip codes. Endothelial dysfunction was measured using the Endo-PAT device, expressed as Framingham reactive hyperemia index (fRHI).Cross-sectional correlates of environmental exposures were assessed in univariate and multivariate linear regression models. Adjustments were made for age, sex, smoking status and race.
Results: Data on environmental pollutants were available on 1717 participants, (66% females, 45% Black; mean (SD) age 58(8) years). Blacks had significantly higher exposure to PM2.5 and BC pollutants compared to Whites. PM2.5 was significantly associated with hypertension, body mass index (BMI), blood glucose, fRHI, and interleukin 6 (IL6). There were weaker associations for BC. The associations of PM2.5 glucose, fRHI and IL6 persisted in fully adjusted model. Associations of BC and these variables were no longer significant in adjusted models.
Conclusion: We found racial disparities in exposure to environmental pollutants in a community-based study. PM2.5 pollutants appeared to be independently associated with elevated blood glucose, worse endothelial function and higher inflammatory marker levels. Further study is needed to understand the role of environmental exposure in racial disparity in CVD.
Author Disclosures: S. Erqou: None. J. Clougherty: None. S. Reis: None.
- © 2016 by American Heart Association, Inc.