Abstract 18093: Effect of Left Ventricular Function on Post Transcatheter Aortic Valve Replacement Hemodynamics
Introduction: Transcatheter aortic valve replacement (TAVR) causes immediate and long term hemodynamic effects that have not yet been clearly defined. This study sought to identify the effect of TAVR on various echocardiographic and hemodynamic parameters.
Methods: 100 consecutive patients who underwent successful TAVR for severe aortic stenosis were evaluated. Clinical, hemodynamic, and echocardiographic data were extracted pre-TAVR, 5 minutes post-TAVR, at 48 hours and at 30 days.
Results: Mean patient age was 84 years, 49% were female, and 87% were of Caucasian race. Mean systolic blood pressure (SBP) was significantly reduced after TAVR at all 3 time points (table), whereas mean diastolic blood pressure was significantly reduced 5 minutes post-TAVR and at 48 hours. Cardiac output and stroke volume were significantly increased and sustained as expected at all time points post-TAVR. There was a significant decrease in SBP immediately and at 48 hours in patients with normal Left ventricular ejection fraction (LVEF) compared to those ≤55% (p=0.0368, p=0.0157 respectively).
Conclusions: Acute increase in cardiac output and stroke volume after TAVR causes a decrease in systemic vascular resistance that is reflected by a concurrent decrease in systolic and diastolic blood pressure. Normal ejection fraction was associated with decrease in systolic blood pressure. Further studies are needed to identify long term trends and identify factors associated with optimal clinical outcome after TAVR.
Author Disclosures: A. Chen: None. V. Parikh: None. A. Brown: None. G. Coffman: None. F. Matar: None. C. Caldeira: None. J. Sullebarger: None. R. Hooker: None. K. Kip: None. A. Labovitz: None. A. Patel: None.
- © 2016 by American Heart Association, Inc.