Abstract 18014: Low Levels of Growth Differentiation Factor 11/8 and High Levels of Its Inhibitor Follistatin-Like 3 Are Associated With Poor Exercise Capacity During a 6-Minute Walk Test
Introduction: Replenishment of Growth Differentiation Factor 11/8 (GDF11/8) to its higher youthful levels improves exercise endurance in old mice. It is unknown if GDF11/8 levels are similarly associated with exercise capacity in humans and if its inhibitor Follistatin-Like 3 (FSTL3) counteracts this effect.
Hypothesis: We hypothesized that low levels of GDF11/8 and high levels of its inhibitor FSTL3 are associated with poor exercise capacity during a 6-minute walk test (6MWT).
Methods: We used aptamer-based proteomics to measure plasma GDF11/8 and FSTL3 levels in subjects with stable coronary heart disease (CHD) from the Heart and Soul Study cohort. Participants who completed the 6MWT and who had GDF11/8 and FSTL3 levels measured (N= 532) were included in the analysis. We used logistic regression to evaluate the association between low and high GDF11/8 and FSTL3 (cutpoint at the median) with low-distance walked during a 6MWT (defined as < 480 meters), adjusting for demographics, cardiovascular risk factors, and co-morbidities.
Results: Crude analyses indicated low GDF11/8 was associated with 70% greater odds of poor exercise capacity compared to high GDF11/8 (OR=1.70, 95% Cl: 1.20, 2.40) (Figure). The association remained after adjustment for age, sex, race, hypertension, CHF, COPD, and eGFR (OR=1.52, 95% Cl: 1.02, 2.27). Crude analyses indicated low FSTL3 had 56% lower odds of having poor exercise capacity compared to high FSTL3 (OR=0.44, 95% Cl: 0.31, 0.63) (Figure). This association remained after adjustment for age, sex, race, BMI, current smoking status, hypertension, and eGFR (OR=0.56, 95% Cl: 0.35, 0.87).
Conclusion: In subjects with stable CHD, low GDF11/8 levels and high levels of its inhibitor FSTL3 are associated with poor exercise capacity during 6MWT.
Author Disclosures: B. Heidecker: None. R.M. Spencer: None. C. Meyer: None. A.L. Beatty: None. M. Whooley: None. P. Ganz: None.
- © 2016 by American Heart Association, Inc.