Abstract 17899: Relationship Between Galectin-3 and Coronary Plaque Burden and Plaque Structure in Obstructive Sleep Apnea Syndrome
Introduction: Obstructive sleep apnea syndrome (OSAS) has been reported to be related with hypertension, coronary artery disease and heart failure in recent studies. Galectin-3 plays an important role in the regulation of inflammation, cardiac fibrosis and remodelling. A significant relationship between galectin-3 and the total number of coronary plaques and the macrocalcified plaque structures of patients with type 2 DM has been reported.
Hypothesis: To investigate the association between galectin-3 and subclinical atherosclerosis indicated by coronary plaque burden and structure detected by coronary computed tomography angiography (CCTA) in OSAS.
Methods: A total of 87 consecutive patients with a diagnosis of OSAS and 21 age and gender-matched control subjects were recruited for the present study. The patients with OSAS were also categorized according to their apnea hypopnea index (AHI) as follows: mild (AHI=5-14.9), moderate (AHI=15-29.9), and severe (AHI≥30). Serum galectin-3 levels were measured with an enzyme-linked immunosorbent assay method.
Results: Mean galectin-3 level was significantly higher in patients with OSAS compared to healthy controls (5.200±1600 ng mL-1 vs. 3.600± 850 ng mL-1, p < 0.001) and in the severe OSAS group compared to the moderate and mild OSAS groups (4.300 ± 1200 ng mL-1, 5.100 ± 1.400 ng mL-1, and 6.400±1700 ng mL-1, respectively, p < 0.001). Correlation analysis indicated significant positive relationships between galectin-3 level and the total number of coronary plaques (p < 0.001), hs-CRP (p = 0.001) and apnea-hypopnea index score (p < 0.001). The discriminatory value of galectin-3 levels for coronary atherosclerosis was assessed by receiver operating curve (ROC) analysis and it revealed a sensitivity of 73.7%, specificity of 77.7% with a cutoff value of > 4.6 ng mL-1 (Area under the curve, 0.803; 95% confidence interval [CI]: 0.720-0.887; p < 0.001). In multivariate analysis, galectin-3 [odds ratio (OR) = 2.16, 95 % CI 1.31-3.22; p = 0.002] was significant independent predictor for coronary atherosclerosis, after adjusting for other risk factors.
Conclusions: Galectin-3 is a novel biomarker that may identify individuals with OSAS, who are potentially at risk of coronary atherosclerosis.
Author Disclosures: H. Pusuroglu: None. U. Somuncu: None. H. Cakmak: None. I. Bolat: None. O. Akgul: None. V. Ornek: None. S. Ozyilmaz: None. H. Yildirim: None. U. Bulut: None. H. Karakurt: None. F. Uzun: None. A. Utkusavas: None.
- © 2016 by American Heart Association, Inc.