Abstract 17866: Long-Term Outcome Following Percutaneous Closure of Isolated Secundum Atrial Septal Defects in Children: A French Nationwide Series of 1000 Consecutive Patients
Introduction: Transcatheter closure has become the preferred treatment strategy in most cases of isolated, secundum atrial septal defect (ASD). Although widely used, data on long-term outcomes in the pediatric population are scarce.
Hypothesis: ASD closure in children provides favourable long term outcome.
Methods: A 1998-2014 retrospective multicentre study was performed at 8 French tertiary institutions, including all patients <18 yo who attempted a percutaneous ASD closure with an Amplatzer Septal Occluder.
Results: 1000 children [38% males, median age: 9 yrs (0.7-18.0), median weight: 27 kg (6-92)] were referred for transcatheter ASD closure. They all had a significant left-to-right shunting assessed by right ventricular dilation and/or a 1.5:1 Qp/Qs ratio; Median ASD size was 15 mm in transthoracic echography (TTE). ASD closure was guided by fluoroscopy and transoesophageal echocardiography in 627 cases (62.7%) or TTE in 373 cases (37.3%). Procedural success rate was 94% with a median occluder size of 19-mm (4 - 40). Device placement was unsuccessful in 60 patients (6%) due to unfavourable anatomy in 38, early device embolization in 12 and other causes in 10 patients. Follow-up (FU) data were available for 829 patients. After a mean FU of 53 ± 31 months (range, 5-204), all patients were alive and 96% were asymptomatic. Long-term complications included supraventricular arrhythmias (n=6) and pulmonary hypertension (n=2). No cardiac erosion, late ASO dislodgement or stroke occurred. Seventy-one women had pregnancy during FU without any associated complication. From an electrical standpoint, supraventricular arrhythmias occurred in 6 patients, no late atrioventricular block was observed and there was no significant difference between preprocedural and last follow-up ECG.
Conclusions: Our large-scale pediatric cohort confirms that transcatheter closure of isolated secundum ASDs is a safe procedure in children, with a favourable long-term outcome and no life-threatening delayed complication.
Author Disclosures: Z. Jalal: Research Grant; Modest; Saint Jude Medical. L. Mauri: None. C. Dauphin: None. C. Gronier: None. S. Hascoet: None. B. Lefort: None. M. Lachaud: None. J. Petit: None. C. Ovaert: None. J. Lusson: None. A. Fraisse: None. X. Pillois: None. J. Thambo: None. A. Baruteau: Research Grant; Modest; Saint Jude Medical.
- © 2016 by American Heart Association, Inc.