Abstract 17865: Leisure Time Physical Activity in Middle Age Participants and Risk of Incident Atrial Fibrillation: A Dose-Response Meta-Analysis
Background: While higher rates of atrial fibrillation (AF) have been observed among athletes, modestly higher levels of leisure time physical activity (LTPA) have been associated with a lower risk of AF in population studies. We sought to conduct a pooled meta-analysis of observational cohort studies to determine if higher levels of LTPA might be associated with an increased risk of AF in the general population.
Methods: Prospective cohort studies that evaluated the relationship between LTPA with incident AF risk among older non-athlete individuals were included in this meta-analysis. LTPA categories across studies were harmonized into 4 groups based on the estimated LTPA levels. The pooled estimate of AF risk with different LTPA categories were determined using the random effects modeling technique described by Dersimonian and Laird.
Results: We included 10 cohort with 265,251 participants (mean age = 58.2 years, % women = 67.7%) and 23,742 incident AF events over a median follow-up of 12.5 years. The weighted average of BMI was 25.6 kg/m2, and the weighted average prevalence of hypertension and diabetes mellitus were 23.6% and 5.4%, respectively. In the pooled analysis, when compared with the lowest LTPA group, AF risk was only modestly lower among individuals in the highest LTPA group (9%; see Table). Similar modest reduction in AF risk was noted in the moderate LTPA group and light LTPA group (6% in both groups).
Conclusion: We observed that higher doses of LTPA were associated with a consistent, modestly lower risk for incident AF. This suggests no increase in AF risk with higher LTPA levels in the general population.
Author Disclosures: N.K. Kulkarni: None. A. Pandey: None. S. Garg: None. B. Park: None. C. Moore: None. H. Mayo: None. J. Joglar: None. R. Wu: None. J. Berry: None.
- © 2016 by American Heart Association, Inc.