Abstract 17852: Prognostic Significance of Ventricular Late Potentials in Patients With Pulmonary Sarcoidosis
Backgrounds: Early detection of cardiac involvement in sarcoidosis is difficult, but important to achieve optimum treatment results. Signal averaged electrocardiography (SAECG) can detect subtle cardiac electrical abnormalities called late potentials (LPs), therefore it may be useful for early diagnosis of cardiac involvement. However, its clinical significance has not been elucidated in detail. The present study seeks to investigate the prevalence and prognostic value of LPs in patients with pulmonary sarcoidosis.
Methods: We prospectively studied 74 pulmonary sarcoidosis patients without ECG abnormalities. All participants underwent SAECG, cardiac echocardiography, and 24-h ambulatory Holter monitoring. Serum angiotensin converting enzyme (ACE) and B-type natriuretic peptide (BNP) levels were also evaluated. We evaluated the incidence of cardiac events including cardiac death, arrhythmias, and heart failure for requiring hospital admission.
Results: Of the studied population, 29 patients (39.2%) had detectable LPs. During a mean follow-up period of 9.4 years, 6 patients with LPs had cardiovascular events, including complete atrioventricular block (n=3), ventricular tachycardia (n=1), and heart failure (n=2). Meanwhile, only 1 of 45 patients without LPs developed cardiac event (heart failure). In univariate analyses, LPs were associated with increased risk of developing cardiac events [hazard ratio (HR) 8.6, 95% confidence interval (CI) 1.0-71.5, P =0.046)], whereas age, gender, serum ACE and BNP levels, number of premature ventricular contractions on 24-h Holter monitoring, and echocardiographic parameters (left ventricular ejection fraction, A/E ratio) were not associated with subsequent cardiac events.
Conclusions: SAECG may be useful for early detection of cardiac sarcoidosis, and it can be applied as screening test for further risk stratification.
Author Disclosures: K. Yodogawa: None. Y. Seino: None. T. Ohara: None. Y. Iwasaki: None. M. Hayashi: None. Y. Miyauchi: None. W. Shimizu: None.
- © 2016 by American Heart Association, Inc.