Abstract 17824: Self-Reported Physical Activity and Coronary Microvascular Dysfunction Are Not Associated in Women With Angina and No Obstructive Coronary Artery Disease
Introduction: Coronary microvascular dysfunction (CMD) is associated with increased cardiovascular morbidity and mortality. The pathophysiology behind CMD remains unknown. Physical inactivity increases cardiovascular risk, and previous small studies in healthy subjects have shown an association between physical activity and CMD.
We investigated whether self-reported physical activity was associated with CMD in women with angina and no obstructive coronary artery disease (CAD).
Method: Women with angina symptoms and a coronary angiogram with no obstructive CAD were included (n=959). CMD was defined as a coronary flow velocity reserve (CFVR) <2 assessed by transthoracic dipyridamole stress echocardiography with Doppler of the left anterior descending artery. Physical activity was assessed by the validated International Physical Activity Questionnaire (IPAQ) and summarized as weekly METs as well as categorized into three groups (low, medium and high physical activity).
Patients with CFVR of poor quality or missing information on IPAQ were excluded, leaving 868 patients eligible for analysis.
Results: Mean (SD) age was 62.3 (9.6) years, body mass index 27.2 (5.3), total weekly METs 3616.8 (3405.2), CFVR 2.42 (0.67). Low physical activity was associated with high body mass index and increased abdominal circumference (p<0.001), but not with other cardiovascular risk factors (table).
We found no significant association between level of physical activity and CFVR (table) or correlation between total weekly METs and CFVR (pearson’s p = 0.801).
Conclusion: Contrary to our hypothesis, self-reported physical activity was not associated with CMD in women with angina and no obstructive CAD. This may be related to insufficient ability of the IPAQ score to differentiate between levels of physical activity. Further studies will determine whether CMD can be modified by exercise training in this patient group.
Author Disclosures: A.B. Rask: None. M.M. Michelsen: None. A. Pena: None. N.D. Mygind: None. D. Frestad: None. H. Suhrs: None. I. Gustafsson: None. H.S. Hansen: None. J. Kastrup: None. P.R. Hansen: None. E. Prescott: None.
- © 2016 by American Heart Association, Inc.