Abstract 17804: Gender Differences in Patients With Ventricular Fibrillation Caused by First ST-segment Elevation Myocardial Infarction
Introduction: Hitherto, no studies have described gender differences in clinical characteristics in patients with ventricular fibrillation (VF) caused by first ST-elevation myocardial infarction (STEMI).
Hypothesis: We hypothesized that clinical characteristics are different between women and men with VF caused by first STEMI.
Methods: Data from the ongoing Danish prospective case-control GEVAMI (GEnetic causes of Ventricular Arrhythmias in patients with first STEMI) study was used for the current study. The case group was patients who experienced VF within the first 12 hours of symptoms of first STEMI and the control group had STEMI without VF. In this study, we compared the clinical characteristics between women and men in the case group. All VF occurred before primary percutaneous intervention (PPCI).
Results: In total, 329 case patients were included of which 53 (16%) were women. Age at the time of VF was 61 years for women and 59 years for men (p=0.300). Compared to men, women experienced more angina within a year prior to VF (58% vs. 42%; p=0.030), were more likely to be treated with beta blockers within a year prior to VF (19% vs. 7%, p=0.020), to be current smokers (71% vs. 52%; p=0.007) and have a history of depression (25% vs. 10%; p=0.002). Women had lower educational level (p=0.008) and personal income per year (p=0.002) across categories. Men had higher alcohol consumption per week (6 drinks per week vs. 3; p=0.045). After adjustment in a logistic regression model the above associations remained significant.
VF occurred more frequently during transport or at arrival to the hospitals (before PPCI) among women (52% vs. 36%; p=0.040). Although women had a longer time from symptom onset to PPCI (166 min. vs. 140 min.; p=0.020) procedural characteristics were not different. Traditional cardiovascular risk factors did not differ between genders (p>0.05 for all).
Conclusion: In conclusion, women with VF were more likely to experience angina, treated with beta blockers, to be current smokers, to have a history of depression, and have a lower educational level and personal income, while men consumed higher levels of alcohol per week. Our data support the hypothesis that gender differences in clinical characteristics exist and merit further investigations.
Author Disclosures: R. Jabbari: None. C. Glinge: None. B. Risgaard: None. T. Lynge: None. B. Winkel: None. S. Haunsø: None. C. Albert: None. T. Engstrøm: None. J. Tfelt-Hansen: None.
- © 2016 by American Heart Association, Inc.