Abstract 17802: Moderate Alcohol Consumption Is Associated With a Decreased Prevalence of Some but Not All Cardio-Metabolic Risk Factors in Young Adults
Introduction: There has been recent debate about whether the benefits of alcohol consumption for cardiovascular health have been overstated due to the use of abstainers as the comparator and inadequate control for confounding factors including physical activity and mental health.
Hypothesis: Moderate consumption, but not abstaining or heavy consumption, will be associated with better cardio-metabolic health in young adults.
Methods: Cross-sectional data from the 2004-06 Childhood Determinants of Adult Health study on alcohol consumption from questionnaire and cardio-metabolic risk factors measured in clinics were used. Linear and log binomial regression were used to examine alcohol consumption (categories: none 0g/day; light >0-10g/day [reference]; moderate >10-20g/day; heavy >20-30g/day; very heavy >30g/day) against dichotomous metabolic syndrome (MetS) (NCEP/ATP III definition), continuous MetS risk score, waist circumference, triglycerides, high-density lipoprotein (HDL) cholesterol, blood pressure (BP), glucose, carotid intima-media thickness, and insulin resistance (HOMA-IR). Covariates included socio-demographics, smoking, diet, physical activity, fitness, depression and anxiety.
Results: Of the 2,220 participants (48% males, mean [SD] age 29.5[2.5] years), most had light alcohol consumption (54.2%), less consumed none (13.2%), heavy (5.2%) or very heavy (5.5%) amounts. Only moderate drinking was associated with a reduced MetS prevalence (prevalence ratio 0.64, p<0.05) compared with light drinking. Increasing alcohol consumption was associated with higher HDL cholesterol (β 0.05, ptrend<0.001) and lower HOMA-IR (β -0.08, ptrend <0.001). Very heavy compared to light consumption was associated with higher systolic (β 3.01 mmHg, p<0.01) and diastolic (β 2.07 mmHg, p<0.05) BP. Effects were similar when inverse probability weighting was used to account for loss to follow-up.
Conclusion: Moderate alcohol consumption was associated with a lower prevalence of MetS and its components even when compared to light consumption and with account for a range of confounding factors; however, the positive association between very heavy drinking and blood pressure in young adults should not be ignored.
Author Disclosures: D.H. Du: None. R. Bruno: None. T. Dwyer: None. A. Venn: None. S. Gall: None.
- © 2016 by American Heart Association, Inc.