Abstract 17726: Left Ventricular Global Longitudinal Strain Predicts All-cause Mortality in Patients With Isolated Mitral Regurgitation
Introduction: Strain echocardiography (echo) is increasingly recognized as an effective technique for predicting patient survival in a wide spectrum of diseases. We sought to evaluate the effectiveness of 2D speckle-tracking echo in predicting all-cause mortality in patients with isolated mitral regurgitation (MR).
Methods: Transthoracic echo examinations were retrieved for patients with mild to severe MR from 2010-2012. After excluding patients with previous CABG, other valvular lesions, valve replacement, congenital heart disease, or incomplete echos, conventional and strain echocardiographic parameters were obtained in 80 patients.
Results: Over mean follow up of 1020 ± 617 days, a total of 33 (41%) patients died. Patients had a mean age of 70 ± 15 years. Thirty (38%) had severe MR. Patients who died had significantly worse global longitudinal strain (GLS) (12.6±3.5% versus 15.8±4.2%; p<0.001). In a multivariate model including age, race, sex, BMI, creatinine, HTN, HLD, diabetes, severity of MR, LA size, LVESD and LVEF, significant predictors of all-cause-mortality were age, creatinine, LVESD and LVEF. When GLS was added to the model it was an independent predictor of mortality (hazard ratio=1.27, 95% CI: 1.08-1.48; P=0.004) in addition to age, creatinine, LVESD and LVEF.
Conclusion: Left ventricular GLS is an independent predictor of all-cause mortality in patients with isolated mitral regurgitation. This can help further risk stratify patients in addition to conventional 2D-echocargraphy parameters such as LVEF and LVESD.
Author Disclosures: D.K. Pu: None. A.A. Holmes: None. N. Wan: None. C. Taub: None.
- © 2016 by American Heart Association, Inc.