Abstract 17718: Depression was Associated With Brain Natriuretic Peptide and Home Morning Systolic Blood Pressure in Male Patients at Risk for Cardiovascular Disease
Introduction: The associations between depression, home blood pressure (BP) and brain natriuretic peptide (BNP) in patients at risk of cardiovascular disease have been unclear.
Hypothesis: We assessed the hypothesis that depression was associated with home BP and BNP.
Methods: We studied 3,830 outpatients who had at least one cardiovascular risk factor (mean age 65±11 years, 46% males). Self-measured home BP was taken for 2 weeks every morning. We examined the relationship between depressive symptoms, as measured by the Beck Depression Inventory (BDI), and BNP. Depression was defined as a BDI score ≥16.
Results: The BDI scores and the prevalence of depression were significantly higher in the females compared to the males (BDI score 10.3±7.5 vs. 7.6±6.4, p<0.001; prevalence of depression 21.4 vs. 11.5%, p<0.001). Among the male patients, home systolic BP (SBP) and BNP in the depressive patients (n=217) were significantly higher than those of the nondepressive patients (n=1,677) (home SBP: 141.0±18.1 vs. 138.7±15.0 mmHg, p=0.001; median BNP: 18.0 vs 15.4 pg/mL, p=0.029). Among the female patients, the home systolic BP and BNP values of the depressive patients (n=455) were also significantly higher than those of the nondepressive patients (N=1,676) (home SBP: 140.2±16.9 vs. 137.4±15.6 mmHg, p=0.001; median BNP: 22.6 vs. 20.4 pg/mL, p=0.001). Office SBP values were similar in the depressive and nondepressive patients of both genders. In the male patients, depression was significantly associated with both home SBP and BNP after adjusting for age, smoking, hypertension, hyperlipidemia, and diabetes (home SBP: F=5.04, p=0.025; BNP: F=6.82, p=0.009), and in the female patients, depression was significantly associated with home SBP after adjusting for the same covariates (F=5.18, p=0.023). The association between depression and BNP disappeared after adjusting for the same covariates in the female patients.
Conclusions: In the patients at risk for cardiovascular disease, depression was associated with home morning systolic BP and BNP, especially in the male patients.
Author Disclosures: T. Kabutoya: None. S. Hoshide: None. K. Kario: Research Grant; Significant; Teijin Pharma Limited, OMRON HEALTHCARE Co., Ltd., FUKUDA DENSHI, Bayer Yakuhin Ltd., A &D Co., Ltd., DAIICHI SANKYO COMPANY, LIMITED., MOCHIDA PHARMACEUTICAL CO., LTD, EA pharma, Otsuka Pharmaceutical Co., Ltd., Boehringer Ingelheim Japan Inc., Mitsubishi Tanabe Pharma Corporation., Medtronic Japan Co., Ltd.. Honoraria; Modest; Mitsubishi Tanabe Pharma Corporation., Kyowa Hakko Kirin Co., Ltd., Bayer Yakuhin Ltd., Pfizer Japan Inc., Shionogi & Co., Ltd., Astellas Pharma Inc., AstraZeneca K.K., Boehringer Ingelheim Japan Inc., Sanofi K.K., TERUMO CORPORATION, Bristol-Myers K.K., Kowa Pharmaceutical Co. Ltd., SANWA KAGAKU KENKYUSHO CO.,LTD., MSD K.K., Actelion Pharmaceuticals Japan, Abott Japan, OMRON HEALTHCARE Co., Ltd., Century Medical Inc., TOA EIYO LTD., MOCHIDA PHARMACEUTICAL CO., LTD, Sumitomo Dainippon Pharma Co., Ltd.. Honoraria; Significant; Takeda Pharmaceutical Company Limited., DAIICHI SANKYO COMPANY, LIMITED., OMRON HEALTHCARE Co., Ltd..
- © 2016 by American Heart Association, Inc.