Abstract 17694: Evaluation of Myocardial Stiffness Change Over Age in Healthy Adult and Hypertrophic Cardiomyopathy Populations Using New Noninvasive Ultrasound Shear Wave Imaging
Objectives: Generated ultrasound shear wave velocity through the myocardium has been validated to be correlated to the shear modulus of the myocardium and therefore to the intrinsic myocardial stiffness (MS, kPa). The goal of our study was to investigate the potential of Myocardial Shear Wave Imaging, to quantify noninvasively the age change of passive diastolic myocardial stiffness in healthy population and its variation vs. hypertrophic cardiomyopathy (HCM) adult populations.
Methods: We included prospectively 40 adults: 30 healthy volunteer (divided into three groups: 20-40 yo (n=10); 40-60 yo (n=10); 60-80 yo (n=10)) and 10 HCM. A complete echocardiography and cardiac magnetic resonance imaging (MRI) were as well achieved in all the study population. MS was evaluated using an ultrafast ultrasound system (Aixplorer, Supersonic Imagine, France) and a phased-array probe (2.75 MHz). The MS estimation was performed on the basal antero-septal segment during the end of the diastole with ECG triggering, in a short axis (SA) and long axis (LA) views. MS were compared between the different groups and analyzed with the clinical parameters of echocardiography and MRI.
Results: For 20-40, 40-60, and 60-80 yo group respectively, the mean SA-MS was 1.21±0.26 kPa, 1.83±0.51 kPa, 2,96±0.44 kPa and the mean LA-MS was 0.74±0.11 kPa, 1.17±0.18 kPa, 1.98±0.53 kPa. MS significantly correlated with age (r2=0.75, p<0,01). There was a significant increase in myocardial stiffness with age (p<0.05 by ANOVA between the 20-40 and 60-80 yo groups). The MS was higher in SA than in LA (p<0.05), due essentially to the local elastic anisotropy of the myocardial muscle. For the HCM (mean SA-MS = 5,47±0,94 kPa; mean LA-MS = 4,14±0,72 kPa), the MS was significantly higher than in the healthy volunteer (p<0,05), independently of age. Positive correlations were found between the MS and diastolic parameters in echocardiography and cardiac MRI (volumes/masses of ventricles, left ventricle wall stress, native T1-mapping).
Conclusion: This MS estimation was found to increase with age in healthy population and was significantly higher in HCM patients. We hope that this new noninvasive parameter will help to better diagnose the diastolic function and its prognosis in clinical practice.
Author Disclosures: O. Villemain: None. M. Correia: None. E. Mousseaux: None. J. Baranger: None. G. Soulat: None. A. Hagège: None. S. Zarka: None. Y. Alattar: None. M. Pernot: None. E. Messas: None.
- © 2016 by American Heart Association, Inc.