Abstract 17685: Characterization of Advanced Lipid Plaque by Optical Frequency Domain Imaging Analysis: A Histopathological Validation Study
Introduction: Optical frequency domain imaging (OFDI) is widely used to characterize lipidic-atherosclerotic plaques, shown as signal-poor regions with diffuse borders, in clinical setting. However, it is difficult to distinguish visually between early stage of atherosclerosis (foam cells accumulation without necrotic core) and advanced lipid plaque (fibroatheroma with necrotic core).
Methods: Thirty lipid plaques of coronary arteries from autopsy hearts after death were analyzed by OFDI and histological assessments. All plaques were classified histologically into two groups: FC-group (n=20) that consisted of foam cells accumulation without necrotic core and NC-group (n=10) that contained fibroatheroma with necrotic core. Longitudinal length of lipid, the maximal lipid arc and an optical attenuation coefficient were measured for each OFDI image corresponding to both the FC-group and the NC-group.
Results: The longitudinal length of lipid was significantly longer in the NC-group than in the FC-group (2.8±1.2 vs. 9.3 vs. 3.3, p<0.001). The maximal lipid arc was also significantly larger in the NC-group as compared with the FC-group (64±35° vs. 140±49°, p<0.001). However, there was no significant deference in the optical attenuation coefficient between two groups (1.56±0.63 vs. 1.52±0.61, p=0.88).
Conclusions: This study revealed the potential capability of OFDI based on longitudinal and circumferential extent of signal-poor lipid plaque for discriminating advanced lipid plaque from early stage of atherosclerosis.
Author Disclosures: T. Imanaka: None. K. Fujii: None. H. Hao: None. M. Shibuya: None. T. Saita: None. K. Kawai: None. K. Akahori: None. T. Horimatsu: None. M. Nishimura: None. N. Yoshihara: None. S. Hirota: None. T. Masuyama: None. M. Ishihara: None.
- © 2016 by American Heart Association, Inc.