Abstract 17680: Dyspnoea and Psychological Distress are Associated With Sleep Quality Over Time in Pulmonary Hypertension
Pulmonary hypertension (PH) is a debilitating condition characterised by progressive fatigue, dyspnoea, and decreased functional capacity. Poor sleep quality has been reported in cross-sectional studies, but there is little longitudinal data. The aims of this study were to measure sleep quality and determine associated factors over 18 months.
Methods: Patients were recruited from 9 specialist centres in the UK and Ireland. Clinical data and measures were collected at baseline, 6, 12 and 18 months: WHO functional class (FC), Sleep Problems Index (SPI), Fatigue Severity Scale (FSS), Hospital Anxiety and Depression Scale (HADS), and Dyspnoea-12. Multi-level linear regression was used to determine factors associated with sleep quality across time.
Results: 185 patients with PH (mean age 56 [sd 13] years, 68% women). Most patients lived with family (76%), few were employed (24%), and most were FC II/III (92%). At baseline sleep quality was poor: 54% scored > 35 indicative of substantial sleep problems (mean SPI 39.4 [sd 19]). Most patients had no anxiety (53%) or depression (66%), mild to moderate dyspnoea, and substantial fatigue. Mean 6 minute walk distances at baseline were 345 (sd 166) metres. Scores did not change significantly over time. Sleep quality did not differ by age, gender, or PH aetiology, but worse FC, fatigue, anxiety, depression and dyspnoea were associated with poor sleep quality. In multivariate analysis only anxiety, depression and dyspnoea were independently associated with sleep quality over time (table).
Conclusions: Poor sleep in PH is persistent and strongly associated with dyspnoea and psychological state. Measuring and addressing these factors as well as sleep hygiene may improve sleep quality and patient well-being.
Author Disclosures: C. Deaton: Research Grant; Modest; Pulmonary Hypertension Association, National Institute of Health Research. I. Armstrong: Research Grant; Modest; Pulmonary Hypertension Association. L. McGowan: Research Grant; Modest; Pulmonary Hypertension Association. P. Sephton: Research Grant; Modest; Pulmonary Hypertension Association. J. Yorke: Research Grant; Modest; Pulmonary Hypertension Association.
- © 2016 by American Heart Association, Inc.