Abstract 17629: Increased Gamma-glutamyltransferase Predicts All-cause Mortality Independently of Coronary Atherosclerosis
Introduction: Several studies have shown that increased gamma-glutamyltransferase (GGT) level is associated with higher cardiovascular mortality. While mechanism for this association is still uncertain, GGT have been shown to be associated with coronary atherosclerosis estimated by coronary artery calcium score (CACS), which is also a strong predictor of cardiovascular events. It is not known whether increased GGT predicts mortality independently of CACS.
Hypothesis: Increased GGT is associated with all-cause mortality after adjustment for CACS and other risk factors.
Methods: From multicenter registry of health screening cohort, 78188 subjects were included in the final dataset for analysis who were without history of ischemic heart disease or stroke and had results of both coronary calcium scoring and GGT. All-cause mortality data were obtained from national mortality registry.
Results: Mean age of study subjects was 51 ± 10 years. Proportion of female was 31 %, 32% was non-drinkers, 17 % had habit of drinking ≥ 3 times/week and 27% had positive coronary calcium. Overall all-cause mortality rate was 0.8% during median follow-up duration of 4.5 (interquartile range 2.9 - 6.4) years. Subjects with increased GGT level were more likely to have coronary calcification (odds ratio (OR) of the highest versus the lowest quartile, 2.42, 95% confidence interval (CI) 2.31 - 2.55) This association persisted after adjustment for age, gender, hypertension, diabetes, smoking, lipid profile, body mass index and metabolic syndrome (OR 1.31, 95% CI 1.21 -1.42). Increased GGT was a significant predictor of all-cause mortality in Cox regression model after adjustment for age, gender, CACS, smoking, fasting glucose, hemoglobin, serum albumin and body mass index (hazard ratio of the highest versus the lowest quartile 2.12, 95% CI 1.57 - 2..83).
Conclusions: Increased GGT level was associated with coronary atherosclerosis and was a predictor of all-cause mortality after adjustment for CACS. Gamma-glutamyltransferase may be a novel cardiovascular risk predictor.
Author Disclosures: J. Sung: None. S. Choi: None. E. Chun: None. H. Han: None. H. Chang: None.
- © 2016 by American Heart Association, Inc.