Abstract 17607: Impact of Red Cell Distribution Width on Long-term Mortality in Patients Treated With Statin After Percutaneous Coronary Intervention
Backgrounds: Many RCTs and meta-analysis have demonstrated statins reduce the risk of cardiovascular events in patients who underwent PCI. However, residual risk still remains even after administration of statins. Recently, red blood cell distribution width (RDW) has been reported as a prognostic marker that reflects oxidative stress and chronic inflammation.
Aims and Methods: The aim of the present study was to investigate the relationship between RDW and mortality in patients treated with statin after percutaneous coronary intervention. This study is consisted of 1076 consecutive patients (mean age, 66.5 years; male, 82%) treated with statins who underwent first PCI from 2005 to 2010. Patients were divided into two groups according to median RDW at baseline (13.1%): a high RDW group (mean RDW 14.0%) and a low RDW group (mean RDW 12.6%). All-cause mortality rates were compared between groups. Mean follow-up was 4.2 years. The cumulative incidence of all-cause mortality was significantly higher in the high RDW group than in the low RDW group (log-rank; p<0.001). Multivariate analysis identified high RDW as associated with all-cause mortality (adjusted HR 1.81, 95%CI 1.16-2.89, P=0.0085).
Conclusions: Increased RDW was significantly associated with increased long-term all-cause mortality in patients treated with statins after PCI.
Author Disclosures: J. Shitara: None. S. Tsuboi: None. K. Miyauchi: None. M. Ogita: None. T. Kasai: None. T. Dohi: None. H. Konishi: None. R. Naito: None. S. Doi: None. H. Wada: None. H. Endo: None. S. Okazaki: None. K. Isoda: None. S. Suwa: None. H. Daida: None.
- © 2016 by American Heart Association, Inc.