Abstract 17603: Optimal Biomarkers for Predicting Incident Coronary Events in Patients With Established Coronary Artery Diseases
Background: Numerous biomarkers have been proposed as potential risk markers for cardiovascular disease (CVD), nevertheless, there is no data on head-to-head comparison among them, and whether the biomarkers, alone or in combination, exhibit incremental value for prediction of CVD.
Methods and Results: Serum adiponectin, adipocytes fatty acid binding protein 4 (A-FABP4), fibroblast growth factor (FGF)-19 and 21, lipocalcin-2 (LCN2), plasminogen activator inhibitor-1 (PAI1) levels were measured in 1289 Chinese subjects with established coronary artery disease (CAD). After a median of 36.2 months follow-up, 96 patients (incidence, 16.8 per 1000 patient-years) developed new onset of an acute coronary syndrome and/or myocardial infarction. Among them, serum FGF-21, LCN2 and A-FABP4 provided better prediction than others with the area under the receiver operating characteristic curves were 0.712 (95% CI, 0.660-0.765, p<0.001), 0.716 (95% CI, 0.665-0.767, p<0.001) and 0.720 (95% CI, 0.670-0.770, p<0.001) respectively after adjusting for risk factors for CVD. Kaplan-Meier analyses showed significantly higher probabilities of CVD events in the presence of high levels of FGF21, LCN2 and A-FABP (log-rank test, all p<0.001, Figure 1). Based on the optimal cutoff values, the C-statistics of FGF-21, LCN2 and A-FABP4 were 0.722, 0.738 and 0.739, respectively, and increased to 0.751 using a combination of LCN2 and A-FABP4 (Figure 2).
Conclusion: While elevated circulating FGF21, LCN2 and A-FABP levels are independent predictors of incident coronary events in Chinese subjects with CAD, the combination of LCN2 and A-FABP can provide a more optimal prediction value.
Author Disclosures: Y. Wong: None. C.Y. Cheung: None. K. Au: None. S. Hong: None. C. Lee: None. J.S. Hai: None. K. Lau: None. T. Lam: None. P. Sham: None. A. Xu: None. K.S. Lam: None. H. Tse: None.
- © 2016 by American Heart Association, Inc.