Abstract 17601: The Relationship of Serum Potassium Level and the Survival Outcomes in Out-of-hospital Cardiac Arrest Patients
Introduction: Potassium has essential role in cellular function. The aim of this study was to evaluate the relationship of serum potassium level and the survival outcomes for out-of-hospital cardiac arrest (OHCA) patients
Methods: This study is prospective study, We used CAPTURES database, which is OHCA cohort of 27 Emergency Department (ED) in Korea , consist of 5 Level 1 ED and 22 Level 2 ED, from February 2014 to January 2015. The inclusion criteria were all OHCA patients in cohort who receive cardiopulmonary resuscitation (CPR) in ED. Patients were excluded if they were transferred from another hospital or had pre-hospital return of spontaneous circulation (ROSC), If the Initial potassium level and clinical outcome data is missing or not captured. Main exposure was Serum potassium concentration on arrival. According to the serum potassium level, Patients were devided into hypokalemia group (K+<3.5mEq/L), normokalemia group (3.5 mEq/L≤K+<5.5 mEq/L) and hyperkalemia group (K+≥5.5 mEq/L). The primary outcome was neurologically favorable survival to discharge. We compared primary outcome between patients who had potassium level higher than 5.5mmol/L level and the others
Results: During study period, 1,616 patients with CAPTURES cohort, 792 patietns were included in analysis. 40 (5.1%) patients were hypokalemia, 318(40.2%) patients were normokalemia, 434(54.8%) patients were hyperkalemia. In hyperkalmia group have significantly lower ratio of good neurologic outcome (1.6%) than normokalemia group (6.2%). And Hypokalemia group have significantly higher ratio of good neurologic outcome (30%). After adjusting covariables, The neurologic outcome of Hyperkalmia group is significantly lower than normokalmia (OR 0.45 95% CI 0.32 - 0.86). And the neurologic outcome of hypokalemia group is significantly higher than normokalemia group (OR 2.8 95% CI 1.08 - 7.22)
Conclusions: In OHCA patients, Hyperkalemia had significant relationship with poor neurologic outcome. And Hypokalmia had relationship with good neurologic outcome.
Author Disclosures: D. Choi: None. Y. Ro: None. S. Shin: None.
- © 2016 by American Heart Association, Inc.