Abstract 17548: Low Serum Triglyceride Level and Low Body Mass Index Associate Increased Risk of Long-term Cardiovascular Mortality in Patients Undergoing Percutaneous Coronary Intervention, 20 Years Follow-up
Introduction: Increased risk of adverse cardiovascular events in patients with low body mass index (BMI) undergoing percutaneous coronary intervention (PCI) has been reported as “obesity paradox”. However, the mechanism of association between low BMI in patients after PCI and adverse outcomes remains obscure. In this study, we therefore hypothesized that low level of serum triglycerides (TG), representing under- or mal-nutrition, is a key to elucidate the mechanism.
Methods: All clinical and prognostic data was collected prospectively as a single-center registry consisting with consecutive 3831 patients undergoing PCI since February 1984 to February 2010, and all the data was analyzed retrospectively.
Results: In this study, we subjected 3599 patients whose data of both BMI and TG are available. Median follow-up period was 8.65 years and its range was 0-20.5 years. Kaplan-Meier survival analysis showed higher cardiovascular mortality in patients with lower than median TG (<121mg/dL), especially in patients with lower than median BMI (<23.8) (p<0.0001) (Figure A). Moreover, univariate Cox proportional hazards analysis for cardiovascular death demonstrated highest hazard ratio (2.96, 95% confidential interval: 2.10-4.17, p<0.01) in patients with lowest quartile of TG (<88mg/dl) and that of BMI (<21.9) (Figure B).
Conclusions: Findings in this long-term prospective observational registry indicate that patients with under-nutrition (low BMI and/or low TG) have increased risk of long-term cardiovascular mortality.
- Percutaneous coronary intervention (PCI)
- Body mass index (BMI) and waist circumference
Author Disclosures: S. Doi: None. H. Iwata: None. R. Naito: None. H. Endo: None. H. Wada: None. H. Konishi: None. S. Tsuboi: None. M. Ogita: None. Y. Kato: None. T. Dohi: None. T. Kasai: None. H. Tamura: None. S. Okazaki: None. K. Miyauchi: None. H. Daida: None.
- © 2016 by American Heart Association, Inc.