Abstract 17390: Association of Arterial Stiffness With Risk of Heart Failure and its Subtypes Among Community-dwelling Participants of the HealthABC Study
Introduction: Higher arterial stiffness is associated with increased risk of adverse CV outcomes such as MI and stroke. However, the association between arterial stiffness and risk of HF and its subtypes, HF with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF), independent of other risk factors is not well established.
Methods: We included participants of the Health ABC study without prevalent HF that had arterial stiffness measured as aortic pulse wave velocity (aPWV) at baseline. Incidence of HF and its subtypes (HFpEF with ejection fraction ≥ 45% & HFrEF with ejection fraction < 45%) was adjudicated on follow-up based on hospital admission records. Adjusted Cox proportional hazard models were constructed to determine the adjusted association between measures of aPWV and incidence of HF, HFrEF, and HFpEF.
Results: We included 2,290 participants (mean age: 74 years, 52.5% women) in the study. In unadjusted comparison, higher aPWV was associated with higher burden of CVD and CV risk factors including hypertension and diabetes. We observed 390 HF events, 162 HFpEF and 145 HFrEF events over 10-year follow-up. In multivariable adjusted analysis, higher aPWV was associated with greater risk of HF after adjustment for age, sex, blood pressure, and heart rate [Model 1 & 2, Figure]. However, this association was attenuated and no longer significant after additional adjustment for other CV risk factors, BMI, physical activity levels, and renal function [Model 3, Figure]. aPWV velocity was also not associated with risk of HFpEF and HFrEF in partially or fully adjusted models.
Conclusion: Arterial stiffness is not independently associated with increased risk of HF or its subtypes after adjustment for traditional CV risk factors. These findings suggest that higher arterial stiffness associated risk of HF is largely mediated by traditional risk factors.
Author Disclosures: A. Pandey: None. H. Khan: None. J. Butler: None. J. Berry: None.
- © 2016 by American Heart Association, Inc.