Abstract 17330: A Resting Blood Pressure Greater Than 130/80 mm Hg Correlates With an Increase in Early Structural and Functional Abnormalities: Time to Re-evaluate the Current Standards of Care
Introduction: Hypertension is a comorbidity that often leads to cardiovascular events, such as strokes, myocardial infarctions, and kidney disease. Current data suggests that hypertension needs to be treated only when the values exceed 140/90 mm Hg.
Hypothesis: To re-evaluate the current recommendations for treatment of hypertension as a preventative measure, to reduce the risk of functional and structural abnormalities in untreated, asymptomatic subjects as assessed by the Early CVD Risk Score (ECVDRS), also known as the Rasmussen Risk Score (RRS).
Methods: A total of 2490 subjects, ages 15-101, were screened for early indicators of cardiovascular disease using the RRS, which consists of a panel of 10 tests; large (C1) and small (C2) artery stiffness, resting BP and post mild exercise, CIMT, abdominal aorta and left ventricle ultrasounds, retinal photography, microalbumuria, ECG, and pro-BNP. 2143 of the subjects were untreated and asymptomatic. The untreated and asymptomatic subjects were then separated based on their resting systolic and diastolic blood pressures and further evaluated for early indicators of CVD risk based on their RRS.
Results: The subjects whose resting blood pressure was greater than 130/80 mm Hg revealed a significant increase in their overall RRS, over those subjects whose resting blood pressure was equal to or less than 130/80 mm Hg. Significant changes were identified in the overall RRS, abnormal rise in blood pressure, C2, CIMT, and microalbumuria as displayed in Figure 1.
Conclusions: The risk of CVD was significantly increased in subjects whose resting blood pressure was greater than 130/80 mm Hg. Current standards of care need to be re-evaluated in order to better prevent future CVD. An ounce of early cardiovascular prevention is worth more than pounds of late cure.
Author Disclosures: S. Tucker: None. A. Byju: None. M. El Shahawy: None.
- © 2016 by American Heart Association, Inc.