Abstract 17290: Metabolomic Signatures of Birth Weight in 18288 Adolescents and Adults
Introduction: Lower birth weight is associated with increased susceptibility to cardiovascular disease and diabetes in adulthood, but the underlying molecular pathways are incompletely understood.
Aims: We examined associations of birth weight with a comprehensive metabolic profile measured in adolescents and adults.
Methods: High-throughput nuclear magnetic resonance metabolomics and biochemical assays were used to quantify 87 circulating metabolic measures in seven cohorts comprising altogether 18,288 individuals (mean age 26, range 15-75). Metabolic biomarker associations with birth weight were adjusted for sex, gestational age, and age at blood sampling. The metabolic associations with birth weight were compared to the corresponding associations with adult BMI.
Results: Lower birth weight was adversely associated with numerous cardiometabolic biomarkers, including amino acids, fatty acids, lipoprotein subclasses, and markers of inflammation and impaired liver function (P<0.001 for 46 measures). Associations were consistent across cohorts with different ages at metabolic profiling, but the magnitudes were weak. The pattern of metabolic deviations associated with lower birth weight resembled the metabolic signature of higher adult BMI (R2=0.77). The resemblance indicated that 1-kg lower birth weight is associated with similar metabolic aberrations as caused by 0.92-units higher BMI in adulthood.
Conclusions: Lower birth weight is associated with adverse biomarker aberrations across multiple metabolic pathways. Coherent metabolic signatures between lower birth weight and higher adult adiposity suggest potentially shared underlying molecular mechanisms. However, the magnitudes of metabolic associations with birth weight are modest in comparison to the effects of adiposity, implying that birth weight is only a weak indicator of cardiometabolic risk in adulthood.
Author Disclosures: P. Wurtz: Employment; Significant; Employee of Brainshake Ltd, a company offering NMR-based metabolomics.. Ownership Interest; Significant; Shareholder of Brainshake Ltd, a company offering NMR-based metabolomics.. Q. Wang: None. M. Niironen: None. J. Kaprio: None. J. Eriksson: None. O. Raitakari: None. D.A. Lawlor: None. G. Davey Smith: None. M. Jarvelin: None. M. Ala-Korpela: Ownership Interest; Significant; Shareholder of Brainshake Ltd, a company offering NMR-based metabolomics. K. Auro: Employment; Significant; Employee of GSK.
- © 2016 by American Heart Association, Inc.