Abstract 17288: Comorbidities Associated With Heart Failure With Preserved Ejection Fraction: A Nationwide Analysis
Background: Among heart failure (HF) patients, the estimated prevalence of heart failure with preserved ejection fraction (HFpEF) is 54%. Several epidemiological studies have identified the clinical phenotype of HFpEF, however the causal relationship and pathogenesis of this syndrome are not fully understood. We aimed to examine the co-morbidities associated with HFpEF using the largest inpatient database to date.
Methods: We performed a cross-sectional analysis using data collected from the Nationwide Inpatient Sample, 2013. ICD-9 codes were used to identify patients with HFpEF and other common co-morbidities including obesity, CAD, atrial fibrillation (AF), type 2 diabetes mellitus (DM), HTN, chronic kidney disease (CKD) and non-alcoholic fatty liver disease (NAFLD). Our primary outcomes were odds of HFpEF with advanced age, gender, race, obesity and other concurrent diagnoses. We performed both univariate and multivariable logistic regression analysis. Data are presented as odds ratio (OR) with 95% confidence interval (CI).
Results: Through an analysis of 6 million hospitalizations (national weighted estimated ~ 30 million hospitalizations) in US hospitals, we identified 251,614 admissions with HFpEF. On multivariate analysis, CAD (OR 1.47, 95% CI 1.45 - 1.49), AF (OR 2.68, 95% CI 2.64 - 2.71), DM (OR 1.35, 95% CI 1.34 - 1.37), HTN (OR 1.26, 95% CI 1.24 - 1.29), CKD (OR 2.49, 95% CI 2.46 - 2.53), obesity (OR 1.53, 95% CI 1.50 - 1.56) and morbid obesity (OR 3.13, 95% CI 3.07 - 3.19) were associated with higher odds of HFpEF (Table1). Interestingly, contrary to previous reports, NAFLD was not associated with increased prevalence of HFpEF. Patient factors associated with increased odds of HFpEF were increasing age, female gender, and black race (compared to white).
Conclusions: Our analysis of 6 million hospitalizations in the US showed increasing age, female gender, black race, obesity, morbid obesity, CAD, DM, HTN, AF and CKD associated with increased odds of HFpEF.
Author Disclosures: V. Anand: None. J. Kealhofer: None. S. Garg: None. S. Bano: None.
- © 2016 by American Heart Association, Inc.