Abstract 17262: Early Repolarization and Risk of Lone Atrial Fibrillation
Introduction: Early repolarization or J wave has recently been associated with an increased risk of idiopathic ventricular fibrillation. Early repolarization syndrome and Brugada syndrome are often accompanied by atrial fibrillation, in addition to ventricular fibrillation. However, the association of early repolarization with risk of atrial fibrillation is unknown.
Hypothesis: Early repolarization indicates the arrhythmogenic substrate for atrial fibrillation as well as that for ventricular fibrillation.
Method: This study included 82 patients (60 men [73.2%]; age, 45±17 years) aged less than 60 years who had paroxysmal lone atrial fibrillation and 410 age- and sex-matched healthy controls (patient: control ratio, 1:5). Patients who had structural heart disease, hypertension, diabetes, hyperthyroidism, resuscitation, or Brugada type electrocardiogram were excluded. Electrocardiograms recorded in the absent of antiarrhythmic drugs during sinus rhythm were compared between patients with atrial fibrillation and healthy controls.
Results: Early repolarization in the inferior and/or lateral leads was more common in patients with atrial fibrillation (26%) than controls (12%) (P=0.002). The location of early repolarization was similar between two groups. Other electrocardiographic measurements including heart rate, PR interval, QRS duration, and QT interval were not different between two groups. Among patients with atrial fibrillation, there was no difference in clinical characteristics including age at atrial fibrillation development, sex, and body mass index between patients with early repolarization and those without early repolarization. Electrocardiographic measurements were not different between patients with early repolarization and those without early repolarization.
Conclusion: Early repolarization was associated with lone atrial fibrillation. Early repolarization may indicate increased susceptibility to atrial fibrillation.
Author Disclosures: Y. Hasegawa: None.
- © 2016 by American Heart Association, Inc.