Abstract 17174: Arterial Hyperoxia Associated With Better Survival Among Resuscitated Patients With Out-of-hospital Cardiac Arrest
Background: Hyperoxia is suggested to be a potential risk factor for mortality of post return of spontaneous circulation (ROSC).
Objective: The purpose of this study was to assess the relationship between the post-ROSC hyperoxia and survival among resuscitated patients with out-of-hospital cardiac arrest (OHCA).
Methods: The CRITICAL study was a multicenter prospective observation using the OHCA database of 11 critical care medical centers in Osaka, Japan. OHCA patients who were attempted resuscitation, transported to participating institutions, and resuscitated from cardiac arrest were included from January 2013 through December 2013. Patients were divided into two groups according to PaO2 level on the first arterial blood gas from post ROSC to admission; hyperoxia of PaO2 of >=300 mmHg and non-hyperoxia of PaO2 of <300 mmHg. Patients receiving extracorporeal cardiopulmonary resuscitation were excluded. Primary outcome was one-month survival. Secondary outcome was neurologically favorable outcome (CPC<=2) at one-month. Multivariable logistic regression adjusting for age, sex, initial shockable rhythm, bystander witness, and therapeutic hypothermia was performed to test the association between PaO2 level and survival.
Results: A total of 678 patients were included in this study. Of them, 83 (12.2%) had hyperoxia and 595 (87.8%) had non-hyperoxia. The hyperoxia group had a significantly higher one-month survival (51.8% [43/83]) than the non-hyperoxia group (31.9% [190/595], P<0.001). Neurologically favorable survival was tended to be higher in the hyperoxia group (20.5% [17/83] in the hyperoxia group vs 15.2% [88/579] in the non-hyperoxia, P=0.250). The odds ratio of hyperoxia for one-month survival after adjusting for age, sex, initial shockable rhythm, bystander witness, and therapeutic hypothermia was 2.10 (95%CI 1.22-3.62).
Conclusion: Among resuscitated OHCA patients, hyperoxia was associated with increased one-month survival.
Author Disclosures: T. Kiguchi: None. T. Kitamura: None. T. Yamada: None. K. Hayakawa: None. K. Yoshiya: None. Y. Abe: None. T. Uejima: None. Y. Yagi: None. S. Nakao: None. M. Kishimoto: None. T. Nishimura: None. T. Sokabe: None. Y. Hayashi: None. T. Morooka: None. J. Izawa: None. T. Shimamoto: None. T. Hatakeyama: None. T. Matsuyama: None. T. Kawamura: None. T. Shimazu: None. S. Fujimi: None. T. Iwami: None.
- © 2016 by American Heart Association, Inc.